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Cancer Liquid Biopsy Market Assessment

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SKU: KLI15527193 Category: Biotechnology Market Research Pages: 91
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  • Table of Contents
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Description

Cancer Liquid Biopsy Market Assessment (Breast Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer, Pancreatic Cancer)

The term liquid biopsy encompasses various diagnostic methods that use liquid, non-tissue specimens to provide information that can aid in the diagnosis, treatment and monitoring of cancer. Currently, tissue biopsies, along with imaging techniques, are the standard methods used in the diagnosis of solid cancers, but despite their widespread use, they have many limitations that open the door for other diagnostic technologies in oncology clinical settings.

This report contains markets for the following:

  • Breast Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Breast Cancer Significant Liquid Biopsy Products on Market
  • Colorectal Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Colorectal Cancer Significant Liquid Biopsy Products on Market
  • Lung Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Lung Cancer Significant Liquid Biopsy Products on Market
  • Ovarian Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Ovarian Cancer Significant Liquid Biopsy Products on Market
  • Pancreatic Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Pancreatic Cancer Significant Liquid Biopsy Products on Market
  • Other Cancer Liquid Biopsy Market (by Region – US, EUR, ASIA, ROW)
  • Other Cancer Significant Liquid Biopsy Products on Market
  • Top Ten Companies in the Market

The currently available liquid biopsy technologies employ the analysis of various types of analytes, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), extracellular vesicles, proteins, miRNA and mRNA. Among them, ctDNA and CTCs have been the most explored technologies for commercial applications up to the present time.

Circulating tumor DNA (ctDNA) encompasses the small fragments of DNA that are believed to originate from the natural and abnormal necrosis and apoptosis processes that tumor cells undergo regularly. ctDNA fragments have the advantage of being available from different types of specimens, including urine, plasma, blood, and cerebrospinal fluid, but are rare and have a short half-life in the bloodstream, which makes their isolation and identification highly challenging. Since many cancer patients shed only very small DNA fragments into the bloodstream, ctDNA-based diagnostic technologies need to be highly sensitive in order to detect such rare events. Furthermore, ctDNA cannot provide information about protein expression, and the analysis of RNA is also difficult and limited using ctDNA. ctDNA may also result from tumor cells killed by therapeutic drugs, and does not capture information about the residual cancer that may not respond to the particular therapy or has become resistant to it.

Circulating tumor cells (CTCs) are cancer cells that are believed to detach from primary or secondary tumors and enter the bloodstream, traveling to distant organs, initiating the process of metastasis, and forming new tumors. Similarly to ctDNA, CTC-based tests could offer significant advantages compared to tissue biopsies, as they may be able to capture the heterogeneity of tumors and their genetic evolution during the disease progression and therapy. Compared to ctDNA, CTCs have a longer half-life in blood, and the analysis of viable cells could provide information about protein expression, such as PD-L1 or ER, which is not possible with ctDNA. Also, since CTCs contain intact genomic material from tumors, their analysis can reveal additional information about the biology of cancer and metastasis that is not possible to obtain from ctDNA.

Exosomes are nanometer-sized extracellular membrane vesicles secreted by cells in the extracellular environment on a continuous basis. Exosomes circulate in great abundance and are highly stable in all biological fluids, and contain molecular information from their parental cells, included in proteins and various nucleic acids. Moreover, exosomes are involved in many cellular processes and carry information about tumor growth, metastasis, and drug resistance, which is not available from the analysis of circulating free DNA. Despite their advantages, the analysis of exosomes for diagnostic purposes poses various challenges that complicate considerably their use in the development of commercial diagnostics. Due to the complex composition of biological fluids, the detection and isolation of high purity exosomes is a long process that imposes the use of multiple techniques based on various parameters.

This report segments market by type of cancer and corresponding regional market. For segmentation by type of analyte and type of application, see Kalorama’s larger study on Liquid Biopsy Markets. ”

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

INTRODUCTION

LIQUID BIOPSY TECHNOLOGIES

INDUSTRY STRUCTURE

LIQUID BIOPSY MARKET REVENUES AND FORECAST

CHAPTER TWO: LIQUID BIOPSY TECHNOLOGIES

INTRODUCTION

Table 2-1 Comparison of Tissue and Liquid Biopsy

CURRENT MAJOR LIQUID BIOPSY TECHNOLOGIES

Table 2-2 Advantages and Limitations of Major Liquid Biopsy Technologies

CIRCULATING FREE DNA

ADVANTAGES AND LIMITATIONS OF CTDNA IN LIQUID BIOPSY

CURRENT CTDNA-BASED LIQUID BIOPSY TESTS

Table 2-3 Selected Market-Available ctDNA-based Liquid Biopsy Tests, 2017

Adaptive Biotechnologies

Biodesix

Epigenomics

Foundation Medicine

Genomic Health

Guardant Health

Myriad Genetics

Pathway Genomics

Personal Genome Diagnostics

QIAGEN

Roche Diagnostics

Sysmex-Inostics

Trovagene

CIRCULATING TUMOR CELLS (CTCS) LIQUID BIOPSY

CHALLENGES IN THE DEVELOPMENT OF CTCS-BASED LIQUID BIOPSY TESTS

CTCS-BASED LIQUID BIOPSY TESTS

Table 2-4 Selected Market-Available CTCs-based Liquid Biopsy Tests, 2017

Biocept

Cynvenio Biosystems

Epic Sciences

GILUPI

Menarini-Silicon Biosystems

QIAGEN

EXTRACELLULAR VESICLES AND OTHER LIQUID BIOPSY

INTRODUCTION

LIQUID BIOPSY TESTS BASED ON EXTRACELLULAR VESICLES

Table 5-1 Selected Liquid Biopsy Tests Based on Extracellular Vesicles/Other Analytes, 2017

Biodesix

Exosome Diagnostics

Gensignia

Hologic

MDxHealth

OncoCyte

QIAGEN

Vermillion

VolitionRx

CHAPTER THREE: LIQUID BIOPSY INDUSTRY ANALYSIS

INTRODUCTION

TIERS OF COMPETITION

Table 3-1 Selected Competitors in the Liquid Biopsy Market, 2017

COMPETITIVE FACTORS

SIGNIFICANT MARKET TRENDS

Table 3-2 Significant Trends in the Liquid Biopsy Diagnostics and Monitoring Tests Market, 2017

Personalized Medicine to Spur Use of Liquid Biopsy Tests in Clinical Practice

Increasing Global Incidence of Cancer and Life Expectancy to Increase Testing Volumes

New Liquid Biopsy Product Launches to Augment Market Revenues

Decreasing Cost of Genetic Testing to Increase Utilization of Liquid Biopsy Tests

Regulatory Hurdles to Limit Market Growth

Limitations in Third-party Payer Coverage to Restrict Test Utilization and Market Growth

Insufficient Demonstrated Clinical Utility to Slow Adoption by Oncologists

Challenges in the Integration of Liquid Biopsy Tests in Clinical Practice to Limit Market Growth

CHAPTER FOUR: CANCER LIQUID BIOPSY MARKET ANALYSIS

OVERALL LIQUID MARKET SNAPSHOT

Table 4-1 Global Liquid Biopsy Market by Type of Cancer ($ millions), 2015-2021

Figure 4-1 Global Liquid Biopsy Market by Type of Cancer ($ millions), 2015-2021

TOP TEN COMPANIES IN THE LIQUID BIOPSY MARKET

Table 4-2 Top Ten Companies in the Liquid Biopsy Market

BREAST CANCER

Market Snapshot

Revenue Forecast

Table 4-3 Breast Cancer Liquid Biopsy Market – by Region (US, EUR, ASIA, ROW)

COLORECTAL CANCER

Market Snapshot

Revenue Forecast

Table 4-4: Colorectal Cancer Liquid Biopsy Market – by Region (US, EUR, ASIA, ROW)

LUNG CANCER

Market Snapshot

Revenue Forecast

Table 4-5: Lung Cancer Liquid Biopsy Market – by Region (US, EUR, ASIA, ROW)

OVARIAN CANCER

Market Snapshot

Revenue Forecast

Table 4-6: Ovarian Cancer Liquid Biopsy Market – by Region (US, EUR, ASIA, ROW)

PROSTATE CANCER

Market Snapshot

Revenue Forecast

Table 4-7: Prostate Cancer Liquid Biopsy Market – by Region (US, EUR, ASIA, ROW)

OTHER CANCERS

Market Snapshot

Revenue Forecast

Table 4-8: Other Cancer Liquid Biopsy Market

 

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