Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

Overview

Scope and Methodology

Introduction to Dentistry

Dentistry Economics

Oral Health and Older Americans

Impact of the Aging Population on Dentistry

Global Dental Market Environment

Global Dental Market

Current Economic Trends

Dental Implants

The Implant Process

Demographics Impact Implant therapy

Shift in Dental Disease Patterns and Treatment Demands

Periodontal Disease: Leading Cause of Edentulism

Candidates for Implants

Types of Dental Implant Devices

Endosseous Implants

Subperiosteal Implants

Transosteal Implants

Implant Surface Treatment Methods

Dental Implant Applications

Single-tooth Implant Restoration

Multiple Tooth Restorations

Full-mouth Restorations

Types of Restoration Procedures

Dental Implant and Abutment Market

Market Forecast

Dental Bone Graft Products and Market

Dental Bone Grafting Materials

Dental Bone Grafting Procedures

Dental Bone Grafting Materials and Products

Dental Bone Graft Products

Dental Bone Graft Market

Market Forecast

CHAPTER TWO: INTRODUCTION TO IMPLANT-BASED DENTAL RECONSTRUCTION: IMPLANT & BONE GRAFT MARKETS

Overview

Brief History of Dentistry

Dentistry Economics

Dental Spending in the U.S.

Major Drivers of Dental Expenditures

Current Economic Trend

Oral Health and the Older Population

Impact of the Aging Population on Dentistry

Oral Health Trends of 65 Years and Older Cohort

Older Patients Present New Challenges for Dentists

Dental market environment

Global Dental Market

Geographic Dental Market

Dental Implants

Overview

Dental Implant Market Potential

Dental implant Applications

Types of Dental Implant Devices

Implant Treatment Process

Dental Bone Grafts

Dental Bone Regeneration Market

Types of Bone Graft Materials

Success Rates of Bone Regeneration

CHAPTER THREE: IMPLANT-BASED DENTAL RECONSTRUCTION, PRODUCTS AND MARKET

Introduction

The Development of Dental Implants: A Brief History

Demographics Impact Utilization of Implants

Shift in Dental Disease Patterns and Treatment Demands

Prevalence of Edentulousness in Adults Aged 65 and Older

Edentulous Rates in Selected Countries

Edentulous Rates in the United States

Factors Affecting Oral Health of Persons 65+

Causes of Tooth Loss

Introduction

Periodontal Disease: Leading Cause of Tooth Loss

Types of Periodontal Diseases

Gingivitis

Aggressive Periodontitis

Chronic Periodontitis

Periodontitis as a Manifestation of Systemic Diseases

Necrotizing Periodontal Diseases

Causes of Periodontal Disease

Genetics

Smoking/Tobacco Use

Hormonal Changes

Stress

Medications

Clenching or Grinding Teeth

Diabetes

Other Systemic Diseases

Poor Nutrition

Periodontal Treatment

Candidates for Implants

Advantages of Dental Implants

Drawbacks of Implants

Cost of Dental Implants

Insurance Coverage for Implants Limited

Complications of Dental Implants

Types of Dental Implant Devices

Endosseous Implants

Root-form Endosseous Implant

Plate-form Endosseous Implant

Ramus-Frame Endosseous Implant

Subperiosteal Implants

Transosteal Implants

Implant Surface Treatments

Grit Blasting

Hydroxyapatite-coating

Plasma Spraying

Dental Implant Applications

Single-tooth Implant Restoration

Multiple Tooth Restorations

Full-mouth Restorations

Implant Restoration Procedures

Evolution of Restoration Procedures and Implant Types

Restoration Procedures

Two-stage Procedure

One-Stage Procedure

Immediate Load Procedure

USA Dental Implant Statistics

Percentage of Dentists Who Have Placed Implants

Average Annual Number of Implants Placed

Average Annual Number of Implants Placed by Dental Specialty

Average Number of Single and Multiple Implants Placed

Dental Implant Device Market

Worldwide Dental Implant Market Potential

Number Procedures Performed

Dental Implant Market and Forecast

Dental Implant Market by World Region

Market Drivers

Leading Dental Implant Competitors

Recent Acquisitions in the Dental Implant Market

CHAPTER FOUR: DENTAL BONE AUGMENTATION, BONE GRAFT PRODUCTS AND MARKET

Overview

Basics of Bone Biology

Osteoblasts

Osteoclasts

Osteocytes

Sequence of Bone Regeneration

Dental Bone Grafting Materials

Autograft or Autogenous Bone Graft

Allograft or Allogenic Bone Graft

Xenograft or Xenogenic Bone Graft

Alloplast or Alloplastic Bone Graft

Growth Factor Enhanced Graft

Dental Bone Grafting Procedures

Nerve Repositioning

Onlay Grafting

Ridge Augmentation

Distraction Osteogenesis

Sinus Lift

Miscellaneous Grafting Procedures

Dental Bone Grafting Materials and Products

Dental Bone Grafting Products

Description of Bone Grafting Products

Dental Bone GRAFT MARKET

Factors Driving the Market

Factors Limiting the Growth of the Market

Market Forecast

World Dental Bone Graft Market by Region

Market Share of the Dental Bone Graft Market

Major Mergers and Acquisitions

CHAPTER FIVE: TRENDS IN IMPLANT-BASED DENTAL RECONSTRUCTION

Manufacturer’s Continue to Improve Implant Systems

Computer-aided Implantology

CAD/CAM Technology

Teeth in an Hour™

Education is Driving the market for implants

Increase in Formal Training Sought for Implant Dentistry

Insurance Coverage For Dental Implants in the U.S.

The Start of a New Trend?

Dental Stem Cells May Grow New Teeth

On-going Dental Stem-cell Research

Odontis Ltd.

Dentigenix, Inc.

CHAPTER SIX: COMPANY PROFILES

Astra Tech Inc.

History and Lines of Business

Dental Implant Products

Financial Information

Biohorizons Implant System, Inc.

History and Lines of Business

Dental Implant Products

Tapered Internal

Single-stage

Internal

External

One-piece 3.0

Overdenture

MinerOss

Biomet 3i, LLC

History and Lines of Business

Dental Implant Products

NanoTite Implant

The Navagator:

External Connection

Internal Connection

Bone Augmention Products

Financial Information

Camlogus

History and Lines of Business

Dental Implant Products

Screw-Line

Root-Line

Cylinder-Line

Screw-Cylinder-Line

Financial Information

Dentsply International, Inc.

History and Lines of Business

Dental Implant Products

Bone Augmentation Products

Accounting Information

Geistlich AG

History and Lines of Business

Bone Augmentation Products

Financial Information

Impladent Limited

History and Lines of Business

Dental Implant Product

Bone Augmentation Product

Keystone Dental, Inc.

History and Lines of Business

Dental Implant Products

XP1 Implant System

Prima Implant System

Restore Implant System

Renova Implant System

Stage-1 Implant System

Bone Augmentation Products

DynaMatrix

DynaBlast and DynaGraft-D

Nobel Biocare USA, Inc.

History and Lines of Business

Dental Implant Products

NobelReplace

NobelActive

NobelSpeedy

Brånemark System

Financial Information

NovaBone, LLC

History and Lines of Business

Dental Bone Augmentation Products

PerioGlas

NovaBone Dental Putty

Osteotech Inc.

History and Lines of Business

Bone Augmentation Products

Financial Information

RTI Biologics, Inc.

History and Lines of Business

Bone Augmentation Products

Puros Block Allograft

Puros Cortical Particulate Allograft

Puros Cancellous Particulate Allograft

Financial Information

Straumann Company

History and Lines of Business

Dental Implant Products

Bone Augmentation Products

Financial Information

Zimmer Dental

History and Lines of Business

Dental Implant Products

Tapered Screw-Vent Implant System.

AdVent Implant System

Tapered SwissPlus System

Bone Augmentation Products

Financial Information

APPENDIX A: COMPANY NAMES & ADDRESSES

APPENDIX B: PROFESSIONAL ORGANIZATIONS & SOCIETIES IN RECONSTRUCTIVE DENTISTRY

LIST OF EXHIBITS

CHAPTER ONE:EXECUTIVE SUMMARY

Exhibit 1-1: Top-selling Implant Device Systems

Exhibit 1-2: Worldwide Dental Implant and Abutment Market, 2003-2013

Exhibit 1-3: Selected Dental Bone Graft Products

Exhibit 1-4: World Dental Bone Graft Market, 2003-2013

CHAPTER TWO: INTRODUCTION TO IMPLANT-BASED DENTAL RECONSTRUCTION: IMPLANT & BONE GRAFT MARKETS

Exhibit 2-1: United States Dental Expenditures, 2002-2017

CHAPTER THREE: IMPLANT-BASED DENTAL RECONSTRUCTION, PRODUCTS AND MARKET

Exhibit 3-1: Dental Implant Placement and Components

Exhibit 3-2: Prevalence of Edentulousness (%) of Elderly Reported for Selected Countries throughout the World, 2000

Exhibit 3-3: Percent of Persons Aged 65+ Years in the U.S. Who have Lost Their Natural Teeth, 2008

Exhibit 3-4: Percentage of Adults Aged 65+ Who Have Lost All of their Natural Teeth, by Selected Characteristics, 2004

Exhibit 3-5: Top Reasons Cited by Periodontists for Tooth Loss That Led to Dental Implant Placement

Exhibit 3-6: Healthy Gums versus Periodontal Disease

Exhibit 3-7: Implant Types and Year Developed

Exhibit 3-8: Percentage of Dentists Who Have Placed a Dental Implant, 1999 and 2006

Exhibit 3-9: Percentage of Dentists Who Have Placed an Implant by Type of Dentistry, 1996, 1999 and 2006

Exhibit 3-10: Average Annual Number of Implants Surgically Placed by Dentists Who Placed Implants, 2002 to 2006

Exhibit 3-11: Average Annual Number of Implants Placed by General Practitioners, Specialists, and all Dentists who Placed Implants, 2006

Exhibit 3-12: Average Number of Single and Multiple Implants Surgically Placed by Dentists, 2006

Exhibit 3-13: Market Potential of Dental Implant Devices in Developed World (Number of Conventionally Treated Patients, Number Treated with Dental Implants, Number of Untreated People Missing Teeth)

Exhibit 3-14: Worldwide Dental Implant and Abutment Market

Exhibit 3-15: Dental Implant Market by World Region, 2008

Exhibit 3-16: World Dental Implant and Abutment Market Revenues and Market Share by Leading Supplier, 2008

Exhibit 3-17: World Dental Implant and Abutment Market, Market Share by Leading Supplier, 2008

Exhibit 3-18: Top-Selling Implant Device Systems (Manufacturer, System, Description)

Exhibit 3-19: Major Acquisitions in the Dental Implant Market, 2007 & 2008

CHAPTER FOUR: DENTAL BONE AUGMENTATION, BONE GRAFT PRODUCTS AND MARKET

Exhibit 4-1: Selected Dental Bone Graft Products

Exhibit 4-2: World Dental Bone Graft Market, 2003-2013

Exhibit 4-3: Dental Bone Graft World Markets by Percent and Revenues, 2008

Exhibit 4-4: Dental Bone Graft Market Share, 2008

Exhibit 4-5: Dental Bone Graft Revenues and Percent Market Share of Major Manufacturers, 2008

Exhibit 4-6: Top-Selling Dental Bone Graft Products

CHAPTER FIVE: TRENDS IN IMPLANT-BASED DENTAL RECONSTRUCTION

Exhibit 5-1: A Selection of CAD/CAM Manufacturers and Products

Exhibit 5-2: Average Annual Number of Implants Placed by General Practitioners, Oral and Maxillofacial Surgeons, and Periodontists, 2002 to 2006

Exhibit 5-3: Percentage of Dentists in Formal Training for Implant Dentistry by Education Category, 2006

Exhibit 5-4: Average Number of Hours Spent in Formal Implant Training for those Dentists Who Have Placeman implant, All Dentists, 1997, 2000 and 2007