Description
The commercial world of medical sensors is vibrant and evolving rapidly. Reports that are only a year or two old are already out-of-date as new technologies make rapid penetration. This new edition attacks the field from the point of view of current R&D, technology and innovation, with an eye to potential markets and emerging technologies in clinical medicine, remote and military applications, process and materials quality control, environmental monitoring, and food and drug quality control.
Technology trends and particulary significant research are discussed and market data (including forecasts through 2009) are segmented by geographical region:
- North America
- European Union
- Japan
- China
- Latin America/Mexico
- India
- Eastern Europe
- Rest of World
And by application and specific measurement
- Research Laboratories
- Medical Applications
- Glucose Biosensors
- Coagulation Rate Biosensors
- Cholesterol Biosensors
- Others
- Industrial Control
- Alcohol (Beverages, Fuel)
- Sugars/Carbohydrates
- Dairy Products
- Meat Products
- Others
- Biodefense
- Environmental
Extensive information on recent patents of note and profiles of almost 100 competitors round out this comprehensive review.
and by application area.
Table of Contents
Chapter One: Executive Summary
- Market Definitions
- Commercialization Challenges
- Development Trends
- Optical Biosensor Innovations
- Microminiaturization of Sensors
- Summary and Comparison of Results
Chapter Two: Introduction
- Definitions and Categories
- Classification of Sensors Based on Analyte
- Classification by Measurement and Control
- Classification by Element and Operation
- Advantages of Biosensors
Chapter Three: Biosensor Technology
- General Biosensor Technology
- Liquid Handling Systems
- Signal Processing and Data Analysis
- Potentiostats
- Software for Biosensor Data Analysis
- Spectroscopic Transduction
- Fourier Transform Infrared Spectroscopy
- Spectrophotometers for Sensor Applications
- Infrared Reflectance Probes
- High-Tech Biosensors
- Miniaturization of Sensors
- Nanoparticle Sensors
- Quantum Dots
- Representative Current High-Tech Biosensor Development Projects
- Smart Sensors
- Biochemical Recognition
- Enzyme Biocatalysts-Based Biosensors
- Enzyme Inhibition
- Bioaffinity-Based Biosensors
- Immunosensors
- Microorganism-Based Biosensors
- Oxygen Demand and Inhibition
- Genetically Engineered Microorganisms
- Signal Transduction
- Potentiometric Transducers
- Amperometric Transducers
- Conductance Measurements
- Optical Measurements
- Fluorescence
- Protein Chip System
- Surface Plasmon Resonance
- Electrochemical Surface Plasmon Resonance (E-SPR)
- SPR Biosensor: Tool for Real-time Analysis of Biomolecular Interactions
- Sensitive Optical Detection
- Sensors Based on the Piezoelectric Effect
- Acoustic Transducers
- Surface Phenomena of Piezoelectric Materials
- Sensor Manufacturing Technologies
- Microfluidics and LOC Technologies
- Microelectronic Manufacturing Technologies
- Monolithic Semiconductor Technologies
- Lithography
- Ceramic-Based Sensors
- Polycrystalline and Vitreous Systems
- Thin- and Thick-film Technologies
- Evaporation and Sputtering
- Processing Polymer Films
- Photolithography
- Electrically Active Polymers
- Fiberoptic Technologies
Chapter Four: Biosensor Applications
- Biomedical Applications
- Special Requirements
- Medical Imaging
- Clinical Diagnosis
- Chemical and Biosensors for Clinical in Vivo Monitoring
- Point of Care Biosensor Applications
- Advances in Point-of-Care Testing
- Future POCT Innovations
- The Future of POCT
- Non-Clinical Diagnostics
- Molecular Diagnostics Clinical Tests and Clusters
- Nanoscale Devices and Nanotechnologies
- Nanotubes for Biological Sensors
- Foodborne Microbial Pathogen Detection
- E. Coli O157:H7
- Liposome-Based Bacteria Sensors
- New Food Sensor Techniques
- New Detection Methods Improve Food Safety
- Monitoring Food for Residues
- Detection of Pathogens and Toxins in Food
- Detection of Listeria Pathogen
- Market Restraints on Food Diagnostics
- Environmental Pollution and Hazard Monitoring
- Monitoring for Toxic Industrial Materials
- Future Directions
- Biowarfare and Bioterrorism
- Bioterrorism Gets Our Attention
- Requirements For Sensing Biological Weapons
- Technologies for Bioagent Detection
- Biosensors for Chemical Agents
- Industrial Process Control
- World Process Analytical Instrumentation Market
- Market Penetration into Nonmedical Applications
Chapter Five: The Biosensor Market
- Market Dynamics and Factors Effecting the Overall Segment
- The Focus is on Development of Applications as well as Sensors
- High Costs of Biosensor Development
- Manufacturing and Product Problems
- Biosensor Development Specialists Work Closely with Users
- Technologies Synergistic with Biosensors are Maturing and Competing
- Impact of Miniaturization and Nanotechnology
- Rapid Development of Microarray Technology Encourages Investment
- Need to Balance Fundamental Research and Application Development
- Older Technologies are Difficult to Replace
- Small Companies with Niche Markets verses Large Companies with Mass Markets
- Factors that are Expanding the Biosensor Market
- Greater Expectations of Quality of Life
- Innovative new Technologies and Applications
- Collaboration among Industrial, Governmental, and Academic Laboratories
- Growing Acceptance of Biosensor Methods
- Successful Biosensors
- Market Data
Chapter Six: Company Profiles
- Abbott Diabetes Care
- Abbott Laboratories
- ABTECH Scientific, Inc.
- Advanced Biosensor Inc.
- Affinity Sensors
- Affymetrix
- Agilent Technologies
- Akubio Ltd
- Alcove Surfaces GmbH
- Alnylam Pharmaceuticals
- Ambri Limited
- AMETEK Princeton Applied Research
- Antibodies Incorporated
- Applera Corporation
- Applied BioPhysics, Inc.
- Archemix Corp.
- BCR Diagnostics Inc.
- BD Biosciences
- Beckman Coulter
- Becton, Dickinson and Company
- Biacore International AB
- BioForce Nanosciences, Inc.
- Biophage Pharma, Inc.
- Biosite Incorporated
- Boston MicroSystems
- Bruker BioSciences Corporation
- Chemel AB
- Cholestech Corporation
- Ciphergen Biosystems
- CombiMatrix Corporation
- Cranfield University — Institute of BioScience and
- Technology
- Cytoplex Biosciences
- Dade Behring Holding Inc.
- Diagnostic Products Corporation
- Diversa Corporation
- DuPont Microcircuit Materials
- Endress+Hauser, Inc.
- Ercon, Inc.
- Evident Technologies
- Farfield Sensors Ltd Unit 51
- FIAlab Instruments, Inc
- HTS Biosystems Incorporated
- Human Genome Sciences
- i-STAT Corporation,
- Ibis Technology Corporation
- Infineon Technologies AG
- Invitrogen Corporation
- Isis Pharmaceuticals, Inc.
- Johns Hopkins University
- Johnson & Johnson
- Luna Analytics
- Matsushita Electric Industrial Co., Ltd.
- MicroFluidic Systems, Inc.
- MicroTEC Gesellschaft für Mikrotechnologie mbH
- Mitsubishi Electric Corporation
- Molecular Devices Corporation
- Molecular Probes, Inc.
- Nanotechnology Institute
- Neogen Corporation
- NeuroMetrix Inc.
- Nitrate Elimination Co., Inc. (NECi)
- Nomadics, Inc.
- Nova Biomedical
- PDSi Pinnacle
- Perkin Elmer
- Perlegen Sciences, Inc.
- PharmaNetics, Inc
- Prolinx, Inc.
- Qiagen
- QMED Inc.
- QTL Biosystems, LLC QTL Biosystems (UK) Ltd.
- Quantum Dot Corp.
- Rapid Biosensor Systems Ltd
- Reichert Analytical Instruments
- Roche Holding Ltd.
- Sensopath Technologies
- Sixth Sense
- Spacelabs Medical, Inc.
- Spectral Diagnostics Inc.
- SpectRx Inc.
- SRU Biosystems, Inc.
- Strategic Diagnostics Inc.
- Tetracore, Inc
- Thermo Electron Corporation
- Thermotron Industries
- Theron, Inc.
- ThreeFold Sensors
- Toshiba Medical Systems
- Transducer Technology, Inc.
- USAID Development Experience Clearinghouse
- XanTec bioanalytics GmbH
- Zyomyx, Inc.
Appendix A: Annotated List of Potentiostat
Manufacturers and Distributors
Appendix B: Ancillary Data Used to Support Market Assumptions
Appendix C: Selected Recent U.S. Patents on Biosensors
List of Exhibits
Chapter one: Executive Summary
- Exhibit 1: Summary: World Market for Biosensors 2004-2009
Chapter two: Introduction
- Exhibit 2: Summary of Common General Biosensor Applications
- Exhibit 3: General Classification of Technologies Used in the Design of Biosensors
- Exhibit 4: List of Specific Biosensor Applications
- Exhibit 5: Sensors Commonly Classified According to the Quantity That They Measure
- Exhibit 6: Important Applications of Biosensors
- Exhibit 7: General Types of Analyte-Bioreceptor Interactions
- Exhibit 8: Biochemical Recognition Molecules—Receptors
- Exhibit 9: Common Transducer Technologies Used in Biosensors Systems
Chapter Three: Biosensor Technology
- Exhibit 10: Commercialization Challenges for General Biosensors
- Exhibit 11: Summary of Selected Commercial Flow Analyzers (Manufacturer, Price, Applications, Flow Diameter/Sample Throughput, Sample Injection/Number/Volume, Detectors, Accessories)
- Exhibit 12: Examples of Sensor Functions Facilitated by Microprocessor and Memory Built into a Smart Sensor
- Exhibit 13: Some Examples of Biomolecular Interactions Which Have Been Successfully Studied Using SPR
- Exhibit 14: Classical Materials and Processing Technologies Used to Fabricate Biosensors
- Exhibit 15: Advantages and Disadvantages of Silicon-Based Sensor Production (Monolithic Semiconductor Processing)
- Exhibit 16: Advantages of Applying Thin and Thick Films in Sensor Fabrication
- Exhibit 17: Advantages and Disadvantages of Applying Polymer Films in Sensors
- Exhibit 18: Some Advantages and Disadvantages of Fiberoptic
Chapter Four: Biosensor Applications
- Exhibit 19: Number of Foodborne Disease Outbreaks and Cases by Etiology 2003 Summary Statistics
- Exhibit 20: Obstacles Common to All Commercially Viable Biosensors Used for Field Analytical Methods
- Exhibit 21: Important Factors in the Selection of Biosensors for Process Control Analyzers
Chapter Five: The Biosensor Market
- Exhibit 22: World Biosensor Market by Geographical Region/Country (North America, European Union, Japan, China, Latin America, India, Eastern Europe, Rest of World) 2004-2009
- Exhibit 23: World Biosensor Market by General Application (Research Laboratories, Medical Applications, Industrial Control, Biodefense, Environmental) 2004-2009
- Exhibit 24: The World Market for Biosensors for Medical Measurement Applications by Application (Blood Glucose, Coagulation Rate, Cholesterol, Others) 2004-2009
- Exhibit 25: The World Market for Biosensors for Industrial Process Control by Type (Alcohol/Beverages/Fuel, Sugars/Carbohydrates, Dairy Products, Meat Products, Others) 2004-2009
Appendix B: Ancillary Data Used to Support Market Assumptions
- Exhibit B-1: World Healthcare Expenditure (Government and Private) by Region, 2004-2009
- Exhibit B-2: World Markets for Bioanalytical Equipment by Type (Total Biohazard Diagnostics, Biochip Systems [LOC, Arrays], Protein Microarrays, and Total Analytical Microarrays), 2004-2009
- Exhibit B-3: Number of Biotech Companies by Region (North America, Europe, Asia/Pacific, Rest of World) 2004-2009
