Table of Contents
ONE: EXECUTIVE SUMMARY
Overview of miRNA and its Potential Applications
miRNA Profiling and Analysis Technologies
qRT-PCR
Hybridization-based Techniques
Next Generation Sequencing
Functional Tools
Industry Structure and Revenues
TWO: INTRODUCTION AND APPLICATIONS OF miRNA
Overview of miRNA Characteristics
Commercial Healthcare-Related Applications of miRNA
Disease Biomarkers
Therapeutic Agents and Targets
THREE: miRNA PROFILING AND FUNCTIONAL ANALYSIS TECHNOLOGIES
qRT-PCR
Overview
Advantages and Limitations of qRT-PCR
Challenges in miRNA profiling by qRT-PCR
Commercial qRT-PCR Products for miRNA Analysis
Selected qRT-PCR Array Platforms
Hybridization-based Techniques
Overview
Selected Commercial Hybridization-based Technologies
Next Generation Sequencing
Overview
Advantages of NGS in miRNA Analysis
Limitations of NGS in miRNA Analysis
NGS Sequencing Platforms
Commercial NGS Library Preparation Kits for miRNA Detection and Profiling
miRNA Functional Analysis Tools
Overview
miRNA Mimics
miRNA Inhibitors
Other Functional Tools – Target Site Blockers/Protectors
FOUR: INDUSTRY STRUCTURE
Tiers of Competition
Barriers to Entry
Technological Know-How/ Intellectual Property
Strong Brand Recognition and Expertise
Sales and Marketing Capabilities/ Distribution Networks
Competitive Factors
Notable Mergers and Acquisitions
ThermoFisher Scientific Acquired Life Technologies and Affymetrix
Merck KGA (Germany) Acquired Sigma-Aldrich
QIAGEN Offers to Buy Exiqon in March 2016
Market Trends
Intensified miRNA-related R&D Activity to Accelerate Market Growth
Increasing Development of miRNA-based Therapeutics and Diagnostics to Spur
Utilization of miRNA Technologies
Growing Utilization of Higher-Priced miRNA Analysis Technologies to Augment
Market Revenues
Availability of Research Funding from Various Entities to Stimulate Utilization of
miRNA Technologies
Limitations of Available Technologies to Restrict Utilization of miRNA Tools
and Services
Lack of Skilled Personnel to Limit Market Growth
Technological Know-How to Hinder Market Expansion
Pricing Pressures to Restrain Market Growth
Total Market Revenues and Forecast
Market Snapshot
Total Market Forecast
Market Revenues and Forecast by Type of Tool
qRT-PCR
Hybridization-based Techniques
NGS
Functional Tools
Market Revenues and Forecast by Type of Service
Competitive Analysis
FIVE: COMPANY PROFILES
Affymetrix
Agilent Technologies
Applied Biological Materials, Inc.
Asuragen, Inc.
Bioneer Corporation
Bio-Rad Laboratories, Inc.
Dharmacon
Exiqon
GeneCopoeia
GenoSensor Corporation
Hummingbird Diagnostics
HTG Molecular Diagnostics, Inc
Illumina, Inc.
Integrated DNA Technologies
LC Sciences, LLC
Luminex Corporation
Miltenyi Biotec GmbH
Mirus Bio, LLC
NanoString Technologies
OriGene Technologies, Inc.
Phalanx Biotech Group
Promega Corporation
QIAGEN N.V.
Quanta BioSciences, Inc.
Regulus Therapeutics
- Hoffmann-La Roche AG
Rosetta Genomics
Sigma-Aldrich Corporation
Thermo Fisher Scientific
Sample Preparation
PCR Instrumentation
qRT-PCR reagents
Next Generation Sequencing
miRNA Mimics and Inhibitors
Toray Industries
WaferGen Bio-systems, Inc.
Wako Pure Chemical Ind. Ltd.
LIST OF EXHIBITS
ONE: EXECUTIVE SUMMARY
Figure 1-1: Historical and Projected Revenues in the Global Market for miRNA Tools and Services, 2013-2016 and 2020
TWO: INTRODUCTION AND APPLICATIONS OF miRNA
Table 2-1: Selected miRNAs Associated with Cancer (Non-small Cell Lung Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma, Leukaemia, Lymphoma, Glioblastoma)
Table 2-2: Selected Extracellular miRNAs Potential Biomarkers in Cardiovascular Disorders (Coronary Arterial Disease, Acute myocardial infarction, Heart Failure)
Table 2-3: Selected miRNAs Associated with Neurological Disorders (Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Epilepsy, Stroke)
Table 2-4: Selected miRNA-based Diagnostic Assays, 2016
Table 2-5: Selected miRNA-based Therapies in Clinical Development, 2016
THREE: miRNA PROFILING AND FUNCTIONAL ANALYSIS TECHNOLOGIES
Table 3-1: Advantages and Limitations of qRT-PCR in miRNA Expression Profiling, 2016
Table 3-2: Selected Challenges in the Profiling of miRNA Expression via qRT-PCR, 2016
Table 3-3: Selected Commercially Available miRNA qRT-PCR Reagents and Kits, 2016
Table 3-4: Advantages and Limitations of Microarrays in miRNA Expression Profiling, 2016
Table 3-5: Selected Commercial Hybridization-based Technologies for miRNA Expression Profiling, 2016
Figure 3-1: Typical Workflow of a miRNA Next-Generation Sequencing Experiment
Table 3-6: Current Advantages and Limitations of NGS in miRNA Profiling, 2016
Table 3-7: Selected Commercial NGS Library Preparation Kits for miRNA Profiling, 2016
Table 3-8: Selected Commercial miRNA Mimics, 2016
Table 3-9: Selected Commercial miRNA Inhibitors, 2016
Table 3-10: Selected Commercial miRNA Target Site Protectors/Blockers, 2016
FOUR: INDUSTRY STRUCTURE
Table 4-1: Industry Structure Summary, 2016
Table 4-2: Industry Structure – Selected Players in the Market for miRNA
Technologies, 2016
Table 4-3: Significant Trends in the Market for miRNA Analysis Tools and Services, 2016 (Near-term Impact [1 year to 2 years], Long-term Impact [3 years to 5 years])
Figure 4-1: Estimated Market Breakdown by Tools and Services, 2015
Figure 4-2: Estimated Market Breakdown by Geographic Region, 2015 (North America, Europe, ROW)
Table 4-4: Global Revenues and Forecast for the miRNA Tools and Services Market, 2013-2016 and 2020 (miRNA Analysis Tools, miRNA Services, Total market)
Figure 4-3: Global Revenues and Forecast for the miRNA Analysis Tools and Services Market, 2013-2016 and 2020
Table 4-5: Global Revenues and Forecast for the miRNA Analysis Tools and Services Market by Geographic Region, 2013-2016 and 2020 (North America, Europe, Rest of World, Total market)
Figure 4-4: Global Revenues and Forecast for the miRNA Analysis Tools and Services Market by Geographic Region, 2013-2016 and 2020 (Rest of World, Europe, North America, Total market)
Table 4-6: Global Revenues and Forecast for the miRNA Analysis Tools Market by Technology, 2013-2016 and 2020 (qRT-PCR, NGS, Hybridization-based, Functional Tools, Total Analysis Tools market)
Figure 4-5: Global Revenues and Forecast for the miRNA Analysis Tools Market by Technology, 2013-2016 and 2020 (Functional Tools, Hybridization-based, NGS,qRT-PCR, Total Market)
Table 4-7: Global Revenues and Forecast for the qRT-PCR Segment of the miRNA Analysis Tools Market, 2013-2016 and 2020
Table 4-8: Global Revenues and Forecast for the Hybridization-based Segment of the miRNA Analysis Tools Market, 2013-2016 and 2020
Table 4-9: Global Revenues and Forecast for the NGS segment of the miRNA Analysis Tools Market, 2013-2016 and 2020
Table 4-10: Global Revenues and Forecast for the Functional Tools Segment of the miRNA Analysis Tools Market, 2013-2016 and 2020
Table 4-11: Global Revenues and Forecast for the miRNA Services Market by Type of Service, 2013-2016 and 2020 (Expression profiling /analysis, Functional analysis, Total services market)
Figure 4-6: Global Revenues and Forecast for the miRNA Services Market, 2013-2016 and 2020 (Functional Analysis, Expression profiling / analysis, Total Market)
FIVE: COMPANY PROFILES
Table 5-1: Selected Companies Offering miRNA-specific Analysis Tools, 2016
