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Proteomics Research Markets: Instruments & Consumables (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other), Market Share and Trends

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SKU: KLI5556567 Categories: Biotechnology Market Research, Proteomics Pages: 165
  • Description
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  • Latest reports

Description

Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays.  Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways.  This report defines the proteomics research market for major technologies.
 
Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis.  As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups:
•      Mass Spectrometry
•      Liquid Chromatography
•      Electrophoresis
Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world.  Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment.  This report also explores proteomics research market by the current and forecast size of disease group market segments that include:
• Oncology
• Neurology
• Cardiovascular
• Other
As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis.  
The report notes the background, products and revenue of the major market players. Companies profiled include:
•        AB Sciex (Danaher) 
•        Agilent Technologies 
•        Bruker Corporation 
•        Thermo Fisher Scientific 
•        Waters Corporation 
•        Bio-Rad Laboratories 
•        GE Healthcare Life Sciences 
•        JEOL Ltd. 
•        Shimadzu Corporation
No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie.  The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis.   Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less’ workflow. 
 
This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications:
• Triple Quadrupole (QqQ)
• Time-of-flight (TOF)
• Quadrupole-TOF (Q-TOF)
• Ion Traps (IT,QIT,LIT)
• Orbitraps
• FT-ICR
The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials.  Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically.
The following is among the topics addressed in this report:
•        Current Practices in Drug Discovery
•        The Translational Research Workflow
•        Proteomics in Biomarker Research           
•        Biomarker Discovery      
•        Biomarker Verification   
•        Biomarker Validation      
•        Company Market Shares by Research Instrument
•        Company Revenues and Detailed Product Offerings
•        Analyst Conclusions Regarding the Present and Future Market
 
Kalorama Information’s market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions.  North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region.  The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions. 
• United States
• Europe 
• Asia-Pacific
• Rest of World (ROW)

Table of Contents

ONE: EXECUTIVE SUMMARY

Background

Proteomics in Translational Research

Proteomics in Biomarker Research

Proteomics in Drug Target Research

Proteomics Research Instruments

Mass Spectrometry

Liquid Chromatography

Electrophoresis

Industry Landscape – Major Competitors

AB Sciex

Agilent Technologies

Bruker Corporation

Thermo Fisher Scientific

Waters Corporation

Major Conclusions

TWO: INTRODUCTION TO PROTEOMICS RESEARCH

Background

Translational Research

Proteomics and the ‘Omics Landscape

The Role of Proteins in Biological Functioning and Disease

Proteins as Biomarkers

Proteomics Research Samples

Conclusion

THREE: PROTEOMICS RESEARCH TECHNOLOGIES

Background

Mass Spectrometry

Triple Quadrupole

Time-of-Flight

Ion Trap / Orbitrap

Ion Sources

Ion Activation

Reagents

Electrophoresis

Gel Electrophoresis

Off-Gel Electrophoresis

GelFree / Continuous Flow Electrophoresis / Free Flow Electrophoresis

Capillary Electrophoresis

Liquid Chromatography

Conclusion

FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT

Background

Proteomics in Biomarker Research

Biomarker Discovery

Biomarker Verification

Biomarker Validation

Proteomics in Drug Target Research (Chemical Proteomics)

Target Deconvolution

Conclusion

FIVE: PROTEOMICS RESEARCH INSTRUMENT MARKETS

Background

Mass Spectrometry Market in Proteomics Research

Liquid Chromatography Market in Proteomics Research

Electrophoresis Market in Proteomics Research

Proteomics Research Market Overview – Technologies, Geographies and Disease

Conclusion

SIX: COMPANY PROFILES

AB Sciex (Danaher)

Background

Products

Revenues

Agilent Technologies

Background

Products

Revenues

Bruker Corporation

Background

Products

Revenues

Thermo Fisher Scientific

Background

Products

Revenues

Waters Corporation

Background

Products

Revenue

Second-Tier Market Players

Bio-Rad Laboratories

Background

Products

GE Healthcare Life Sciences

Background

Products

JEOL Ltd.

Background

Products

Shimadzu Corporation

Background

Products

LIST OF EXHIBITS

ONE: EXECUTIVE SUMMARY

Figure 1-1: Translational Research Workflow Schematic

Table 1-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,

Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost

Table 1-2: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)

Table 1-3: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)

Figure 1-2: Proteomics Research Market by Company Share (AB Sciex, Agilent, Bio-Rad Laboratories, Bruker, GE Healthcare Life Sciences, Thermo Fisher Scientific, Waters, Other) (2015)

TWO: INTRODUCTION TO PROTEOMICS RESEARCH

Figure 2-1: Translational Research Workflow Schematic

Figure 2-2: Systems Biology Schematic (Genome, Transcriptome, Proteome,Metabolome)

Table 2-1: Proteomics Research Sample Comparison by Advantages/Disadvantages –Cell Culture, Dried Blood Spot, Plasma, Serum, Tissue, Whole Blood

THREE: PROTEOMICS RESEARCH TECHNOLOGIES

Table 3-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost

Table 3-2: Triple Quadrupole Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)

Table 3-3: Time-of-Flight / TOF Hybrid Parameters and Summary (Resolution,Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed,

Advantages/Disadvantages)

Table 3-4: Fourier Transform Ion Cyclotron Resonance Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)

Table 3-5: Quadrupolar, Linear and Hybrid Ion Trap Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)

Table 3-6: Orbitrap Parameters and Summary (Resolution, Mass Accuracy,Sensitivity, Mass Range, Dynamic Range, Cost, Speed,Advantages/Disadvantages)

Table 3-7: Major Vendor Electrospray Ionization Innovations Summary

Table 3-8: Surface Analysis Ionization Technique Advantages/Disadvantages(MALDI, SELDI, DESI, LAESI)

Table 3-9: Ion Activation Method Advantages/Disadvantages (Low-Energy CID,High-Energy CID, SID, PSD, ISD, UVPD, IRMPD, ECD, ETD)

Table 3-10: Electrophoresis Method Advantages/Disadvantages (SDS-PAGE, 2DGE,DIGE, OFFGEL, GELFREE, Continuous and Free Flow, Capillary)

FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT

Table 4-1: Shotgun Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)

Table 4-2: Gel-Based Discovery Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)

Table 4-3: Capillary Electrophoresis-Based Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)

Table 4-4: Data-Independent Acquisition Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)

Table 4-5: Major Vendor DIA Product Comparison (Waters MSE, Thermo Fisher AIF,AB Sciex SWATH, Thermo Fisher MSX, Thermo Fisher PRM)

Table 4-6: Selected and Multiple Reaction Monitoring (SRM/MRM) Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)

Table 4-7: Chemical Proteomics/Drug Target Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)

FIVE: ROTEOMICS RESEARCH INSTRUMENT MARKETS

Table 5-1: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)

Table 5-2: Proteomics Research Mass Spectrometry Market by Company Share(2015)

Table 5-3: Proteomics Research Liquid Chromatography Market (2015/2020)

Table 5-4: Proteomics Research Liquid Chromatography Market by Company Share(2015)

Table 5-5: Proteomics Research Electrophoresis Market (2015/2020)

Table 5-6: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)

Table 5-7: Proteomics Research Market by Geography (North America, Europe, Asia-Pacific, ROW) (2015/2020)

Table 5-8: Proteomics Research Market by Disease Area (Cardiovascular, Neurology, Oncology, Other) (2015)

SIX: COMPANY PROFILES

Table 6-1: AB Sciex Proteomics Products

Table 6-2: AB Sciex Revenue (2009-2014)

Table 6-3: Agilent Technologies Proteomics Products

Table 6-4: Agilent Technologies Revenue (FY 2009-2014)

Table 6-5: Bruker Corporation Proteomics Products

Table 6-6: Bruker Corporation Revenue (2009-2014)

Table 6-7: Thermo Fisher Scientific Proteomics Products

Table 6-8: Thermo Fisher Scientific Revenue (2009-2014)

Table 6-9: Waters Corporation Proteomics Products

Table 6-10: Waters Corporation Revenue (2009-2014)

Table 6-11: Bio-Rad Laboratories Proteomics Products

Table 6-12: GE Healthcare Life Sciences Proteomics Products

Table 6-13: JEOL Ltd. Proteomics Products

Table 6-14: Shimadzu Corporation Proteomics Products

 

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