Description
Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays. Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways. This report defines the proteomics research market for major technologies.
Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis. As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups:
• Mass Spectrometry
• Liquid Chromatography
• Electrophoresis
Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world. Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment. This report also explores proteomics research market by the current and forecast size of disease group market segments that include:
• Oncology
• Neurology
• Cardiovascular
• Other
As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis.
The report notes the background, products and revenue of the major market players. Companies profiled include:
• AB Sciex (Danaher)
• Agilent Technologies
• Bruker Corporation
• Thermo Fisher Scientific
• Waters Corporation
• Bio-Rad Laboratories
• GE Healthcare Life Sciences
• JEOL Ltd.
• Shimadzu Corporation
No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie. The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis. Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less’ workflow.
This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications:
• Triple Quadrupole (QqQ)
• Time-of-flight (TOF)
• Quadrupole-TOF (Q-TOF)
• Ion Traps (IT,QIT,LIT)
• Orbitraps
• FT-ICR
The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials. Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically.
The following is among the topics addressed in this report:
• Current Practices in Drug Discovery
• The Translational Research Workflow
• Proteomics in Biomarker Research
• Biomarker Discovery
• Biomarker Verification
• Biomarker Validation
• Company Market Shares by Research Instrument
• Company Revenues and Detailed Product Offerings
• Analyst Conclusions Regarding the Present and Future Market
Kalorama Information’s market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions. North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region. The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions.
• United States
• Europe
• Asia-Pacific
• Rest of World (ROW)
Table of Contents
ONE: EXECUTIVE SUMMARY
Background
Proteomics in Translational Research
Proteomics in Biomarker Research
Proteomics in Drug Target Research
Proteomics Research Instruments
Mass Spectrometry
Liquid Chromatography
Electrophoresis
Industry Landscape – Major Competitors
AB Sciex
Agilent Technologies
Bruker Corporation
Thermo Fisher Scientific
Waters Corporation
Major Conclusions
TWO: INTRODUCTION TO PROTEOMICS RESEARCH
Background
Translational Research
Proteomics and the ‘Omics Landscape
The Role of Proteins in Biological Functioning and Disease
Proteins as Biomarkers
Proteomics Research Samples
Conclusion
THREE: PROTEOMICS RESEARCH TECHNOLOGIES
Background
Mass Spectrometry
Triple Quadrupole
Time-of-Flight
Ion Trap / Orbitrap
Ion Sources
Ion Activation
Reagents
Electrophoresis
Gel Electrophoresis
Off-Gel Electrophoresis
GelFree / Continuous Flow Electrophoresis / Free Flow Electrophoresis
Capillary Electrophoresis
Liquid Chromatography
Conclusion
FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT
Background
Proteomics in Biomarker Research
Biomarker Discovery
Biomarker Verification
Biomarker Validation
Proteomics in Drug Target Research (Chemical Proteomics)
Target Deconvolution
Conclusion
FIVE: PROTEOMICS RESEARCH INSTRUMENT MARKETS
Background
Mass Spectrometry Market in Proteomics Research
Liquid Chromatography Market in Proteomics Research
Electrophoresis Market in Proteomics Research
Proteomics Research Market Overview – Technologies, Geographies and Disease
Conclusion
SIX: COMPANY PROFILES
AB Sciex (Danaher)
Background
Products
Revenues
Agilent Technologies
Background
Products
Revenues
Bruker Corporation
Background
Products
Revenues
Thermo Fisher Scientific
Background
Products
Revenues
Waters Corporation
Background
Products
Revenue
Second-Tier Market Players
Bio-Rad Laboratories
Background
Products
GE Healthcare Life Sciences
Background
Products
JEOL Ltd.
Background
Products
Shimadzu Corporation
Background
Products
LIST OF EXHIBITS
ONE: EXECUTIVE SUMMARY
Figure 1-1: Translational Research Workflow Schematic
Table 1-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,
Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost
Table 1-2: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)
Table 1-3: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)
Figure 1-2: Proteomics Research Market by Company Share (AB Sciex, Agilent, Bio-Rad Laboratories, Bruker, GE Healthcare Life Sciences, Thermo Fisher Scientific, Waters, Other) (2015)
TWO: INTRODUCTION TO PROTEOMICS RESEARCH
Figure 2-1: Translational Research Workflow Schematic
Figure 2-2: Systems Biology Schematic (Genome, Transcriptome, Proteome,Metabolome)
Table 2-1: Proteomics Research Sample Comparison by Advantages/Disadvantages –Cell Culture, Dried Blood Spot, Plasma, Serum, Tissue, Whole Blood
THREE: PROTEOMICS RESEARCH TECHNOLOGIES
Table 3-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,Orbitrap, FT-ICR) – Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost
Table 3-2: Triple Quadrupole Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
Table 3-3: Time-of-Flight / TOF Hybrid Parameters and Summary (Resolution,Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed,
Advantages/Disadvantages)
Table 3-4: Fourier Transform Ion Cyclotron Resonance Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)
Table 3-5: Quadrupolar, Linear and Hybrid Ion Trap Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)
Table 3-6: Orbitrap Parameters and Summary (Resolution, Mass Accuracy,Sensitivity, Mass Range, Dynamic Range, Cost, Speed,Advantages/Disadvantages)
Table 3-7: Major Vendor Electrospray Ionization Innovations Summary
Table 3-8: Surface Analysis Ionization Technique Advantages/Disadvantages(MALDI, SELDI, DESI, LAESI)
Table 3-9: Ion Activation Method Advantages/Disadvantages (Low-Energy CID,High-Energy CID, SID, PSD, ISD, UVPD, IRMPD, ECD, ETD)
Table 3-10: Electrophoresis Method Advantages/Disadvantages (SDS-PAGE, 2DGE,DIGE, OFFGEL, GELFREE, Continuous and Free Flow, Capillary)
FOUR: PROTEOMICS RESEARCH PROCESSES – BIOMARKER AND DRUG TARGET DEVELOPMENT
Table 4-1: Shotgun Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
Table 4-2: Gel-Based Discovery Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)
Table 4-3: Capillary Electrophoresis-Based Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
Table 4-4: Data-Independent Acquisition Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
Table 4-5: Major Vendor DIA Product Comparison (Waters MSE, Thermo Fisher AIF,AB Sciex SWATH, Thermo Fisher MSX, Thermo Fisher PRM)
Table 4-6: Selected and Multiple Reaction Monitoring (SRM/MRM) Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
Table 4-7: Chemical Proteomics/Drug Target Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)
FIVE: ROTEOMICS RESEARCH INSTRUMENT MARKETS
Table 5-1: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)
Table 5-2: Proteomics Research Mass Spectrometry Market by Company Share(2015)
Table 5-3: Proteomics Research Liquid Chromatography Market (2015/2020)
Table 5-4: Proteomics Research Liquid Chromatography Market by Company Share(2015)
Table 5-5: Proteomics Research Electrophoresis Market (2015/2020)
Table 5-6: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)
Table 5-7: Proteomics Research Market by Geography (North America, Europe, Asia-Pacific, ROW) (2015/2020)
Table 5-8: Proteomics Research Market by Disease Area (Cardiovascular, Neurology, Oncology, Other) (2015)
SIX: COMPANY PROFILES
Table 6-1: AB Sciex Proteomics Products
Table 6-2: AB Sciex Revenue (2009-2014)
Table 6-3: Agilent Technologies Proteomics Products
Table 6-4: Agilent Technologies Revenue (FY 2009-2014)
Table 6-5: Bruker Corporation Proteomics Products
Table 6-6: Bruker Corporation Revenue (2009-2014)
Table 6-7: Thermo Fisher Scientific Proteomics Products
Table 6-8: Thermo Fisher Scientific Revenue (2009-2014)
Table 6-9: Waters Corporation Proteomics Products
Table 6-10: Waters Corporation Revenue (2009-2014)
Table 6-11: Bio-Rad Laboratories Proteomics Products
Table 6-12: GE Healthcare Life Sciences Proteomics Products
Table 6-13: JEOL Ltd. Proteomics Products
Table 6-14: Shimadzu Corporation Proteomics Products
