Table of Contents
1: EXECUTIVE SUMMARY
OVERVIEW
METHODOLOGY
MARKET OVERVIEW
Table 1: World Market for Single Use Upstream Processing, 2016-2021 ($ millions) (Single Use Bioreactors, Single Use Media Bags, Single Use Bioprocess Containers, Single Use Tubing and Connectors, Single Use Mixing Systems, Single Use Pressure Sensors and Probes, Single Use Temperature Sensors and Probes, Single Use pH Sensors and Probes, Single Use Dissolved Oxygen Sensors and Probes, Single Use Other Probes and Sensors, World Totals)
Figure 1: World Market for Single Use Upstream Processing, 2016-2021 ($ millions) (Single Use Bioreactors, Single Use Media Bags, Single Use Bioprocess Containers, Single Use Tubing and Connectors, Single Use Mixing Systems, Single Use Pressure Sensors and Probes, Single Use Temperature Sensors and Probes, Single Use pH Sensors and Probes, Single Use Dissolved Oxygen Sensors and Probes, Single Use Other Probes and Sensors, World Totals)
Figure 2: World Market for Single Use Upstream Processing by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, Latin America, ROW)
2: INTRODUCTION
UPSTREAM BIOPROCESSING PERSPECTIVE
Bioreactors
Single Use Bioreactors
Other Single Use Products
TRADITIONAL PROCESSING
DISPOSABLE PROCESSING
Methodical Progress
Components and Regulation
Some Impediments
But Biosimilar and Biologics Opportunities
VARIATIONS IN BIOREACTOR TYPES
Stainless Steel
Stirred-Tank Reactors
Airlift Fermenters
Packed Bed Reactors
Hollow-Fiber Reactors
Single Use Systems
Table 2. Traditional and Single Use Bioreactor Features
FLEXIBILITY
Vaccine Manufacture
Product Variety
BUT CHALLENGES LOOM
Alternating Scales
Automation
Compliance
Distribution
Integrity
YET OPPORTUNITIES IN TARGETED THERAPEUTICS
Newer Protein Therapies
Cell-Culture-Based Technology
Cost-Effective Solution
Outsourcing Continues
Capacity Investment Shifting
3: SINGLE USE BIOPROCESSING TRENDS
ROBUST EXPANSION
PRODUCT TITER GROWTH
PERFUSION
Intensified Perfusion
RETROFITTING FACILITIES
FLEXIBILITY
CELL RETENTION AND CAPACITY
REDUCING UTILITY COSTS
MODULAR FACILITIES
LOCAL PRODUCTION
4: ISSUES FACING SINGLE USE BIOPROCESSING
SINGLE USE OR STAINLESS
SOME COSTS INVOLVED
VENDOR AUDITING
REGULATORY CHALLENGES
Leaching
QUALIFYING VENDORS
Plastic Purity
CUSTOMIZATION
STANDARDIZATION
5: MARKET DEVELOPMENTS
4,000 LITER SINGLE-USE BIOREACTOR INSTALLED
DISPOSABLE MIXING SYSTEMS
SMART SENSORS
NON-GMP PILOT PLANT
CONTINUOUS BIOPROCESS LABORATORY
DISPOSABLE TECHNOLOGIES FOR SCALE UP
MAXIMIZING EFFICIENCY – CUSTOMIZATION
SINGLE USE STORAGE CONTAINERS
SINGLE USE SPECIALIST
DRIVING SINGLE USE
NEW TEST CENTER
NEW MODULAR FACILITY SYSTEM
SINGLE USE FOR CELL THERAPY
6: MARKET LANDSCAPE
EARLY PENETRATION
NICHE OPPORTUNITIES
INTEGRAL TO BIOPROCESSING
DEMAND FROM LOCAL MARKETS
MARKET DISRUPTION
BEYOND THE SMALL SCALE
DIFFERENT MANUFACTURING OPTIONS POSSIBLE
OPPORTUNITIES FOR SUPPLIERS
SMALLER TARGETED MARKETS
Table 3. Single Use Technology Utilization (%)
MARKETS IN TRANSITION
Diversity
Continuous Flow Processing
More Responsive Supply Chain
Drivers
Table 4. Key Drivers of Single Use Systems
7: MARKET ANALYSIS AND FORECASTS
WIDE ACCEPTANCE WORLDWIDE
Emerging Markets
STAINLESS STEEL STILL COMPETITIVE
Table 5. Single Use Bioreactor Usage by Process 2018 (%)
Table 6. Single Use Bioprocessing Market Share by Vendor 2018 (%)
SINGLE USE BIOREACTORS
Table 7. Single Use Bioreactor Market Share by Type of Molecule, 2018 (%)
Table 8. World Market for Single Use Bioreactors, 2016-2021 ($ millions)
Table 9. World Market for Single Use Bioreactors by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
SINGLE USE MEDIA BAGS
Table 10. World Market for Single Use Media Bags, 2016-2021 ($ millions)
Table 11. World Market for Single Use Media Bags by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
SINGLE USE BIOPROCESS CONTAINERS
Table 12. World Market for Single Use Bioprocess Containers, 2016-2021 ($ millions)
Table 13. World Market for Single Use Bioprocess Containers by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
SINGLE USE TUBING AND CONNECTORS
Table 14. World Market for Single Use Tubing and Connectors, 2016-2021 ($ millions)
Table 15. World Market for Single Use Tubing and Connectors by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
SINGLE USE MIXING SYSTEMS
Table 16. World Market for Single Use Mixing Systems, 2016-2021 ($ millions)
Table 17. World Market for Single Use Mixing Systems by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
SINGLE USE SENSORS AND PROBES
Table 18. World Market for Single Use Sensors and Probes, 2016-2021 ($ millions)
Table 19. World Market for Single Use Sensors and Probes by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
Single Use Pressure Sensors and Probes
Table 20. World Market for Single Use Pressure Sensors and Probes, 2016-2021 ($ millions)
Table 21. World Market for Single Use Pressure Sensors and Probes by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
Single Use Temperature Sensors and Probes
Table 22. World Market for Single Use Temperature Sensors and Probes, 2016-2021 ($ millions)
Table 23. World Market for Single Use Temperature Sensors and Probes by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
Single Use pH Sensors and Probes
Table 24. World Market for Single Use pH Sensors and Probes, 2016-2021 ($ millions)
Table 25. World Market for Single Use pH Sensors and Probes by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
Single Use Dissolved Oxygen Sensors and Probes
Table 26. World Market for Single Use Dissolved Oxygen Sensors and Probes, 2016-2021 ($ millions)
Table 27. World Market for Single Use Dissolved Oxygen Sensors and Probes by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC, China, Japan, S. Korea, India, Others, Latin America, ROW)
8: CORPORATE PROFILES
ABEC, BETHLEHEM, PA 18017, WWW.ABEC.COM
APPLIKON BIOTECHNOLOGY, DELFT, NETHERLANDS, WWW.APPLIKON-BIO.COM
BROADLEY-JAMES CORP., IRVINE, CA 92618, WWW.BROADLEYJAMES.COM
CELLEXUS, DUNDEE, UK, WWW.CELLEXUS.COM
CELLON SA, GRAND DUCHÉ DU LUXEMBOURG, WWW.CELLON.LU
CELLTAINER BIOTECH BV, WINTERSWIJK BRINKHEURNE, THE NETHERLANDS, WWW.CELLTAINER.COM
CERCELL APS, HOLTE DENMARK, WWW.CERCELL.COM
CPC (COLDER PRODUCTS COMPANY), ST. PAUL, MN 55114, WWW.CPCWORLDWIDE.COM
CRONUS-PCS, DK-2840 HOLTE, DENMARK, WWW.CRONUS-PCS.COM
EIRECHROM, MAHON, CO. CORK, T12 W7CV IRELAND, WWW.EIRECHROM.IE
EPPENDORF, HAMBURG, GERMANY, WWW.EPPENDORF.COM/US-EN/
ESI ULTRAPURE, CWMBRAN, TORFAEN, NP44 3XS, UK, WWW.ESITECHGROUP.COM
FINESSE SOLUTIONS, SANTA CLARA, CA 95054, WWW.FINESSE.COM
GE HEALTHCARE’S LIFE SCIENCES BUSINESS, PITTSBURGH, PA 15264, WWW.GELIFESCIENCES.COM/WEBAPP/WCS/STORES/SERVLET/CATALOG/EN/GELIFESCIENCES-US/BRANDS/XCELLEREX
HAMILTON ROBOTICS, BONADUZ, SWITZERLAND, WWW.HAMILTONCOMPANY.COM
HOLLAND APPLIED TECHNOLOGIES, BURR RIDGE, IL 60527, HTTP://WWW.HOLLANDAPT.COM
MILLIPORE, MILLIPORE SIGMA, BURLINGTON, MA 01803, WWW.EMDMILLIPORE.COM
NEWAGE INDUSTRIES, SOUTHAMPTON, PA 18966, WWW.NEWAGEINDUSTRIES.COM
PALL BIOTECH, PORT WASHINGTON, NY 11050, HTTPS://BIOTECH.PALL.COM
PARKER HANNIFIN, CLEVELAND, OH 44124, WWW.PARKER.COM
PBS BIOTECH, CAMARILLO, CA 93012, WWW.PBSBIOTECH.COM
PENDOTECH, PRINCETON, NJ 08542, WWW.PENDOTECH.COM
PERFUSECELL A/S, DK-2840 HOLTE, DENMARK, WWW.PERFUSECELL.COM
PRESENS PRECISION SENSING, 93053 REGENSBURG, GERMANY, WWW.PRESENS.DE
PROLIFECELL, DK-2840 HOLTE, DENMARK, WWW.PROLIFECELL.COM/PRODUCT
PUMPCELL A/S, DK-2840 HOLTE, DENMARK, WWW.PUMPCELL.COM
REFINE TECHNOLOGY, PINE BROOK, NJ 07058, WWW.REFINETECH.COM
SARTORIUS AG, GOETTINGEN, GERMANY, WWW.SARTORIUS.COM
STOBBE TECH, DK-2840 HOLTE, DENMARK, WWW.STOBBE.COM/RESEARCH/BIOTECH/GLYCOCELL
SYSBIOTECH, PERIGNY FRANCE, WWW.SYSBIOTECH.EU
THERMO FISHER SCIENTIFIC, WALTHAM, MA 02451, WWW.THERMOFISHER.COM/US/EN/HOME/LIFE-SCIENCE/BIOPRODUCTION/SINGLE-USE-BIOPROCESSING.HTML
ZETA HOLDING, GRAZ, AUSTRIA, WWW.ZETA.COM
