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The Global Market for Biomarkers (Cancer Markers, Cardiac Markers, Blood Markers, Endocrine Markers, Infectious Disease and Neurological Disease Markers)

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SKU: KLI5136277 Category: Biotechnology Market Research Pages: 330
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Description

The effectiveness of biomarkers has made them essential to medicine, with successful products on the market and many products in development.   This Kalorama Information report focuses on both the clinical biomarkers and research biomarkers in medicine.

Biomarkers are physiologic, genetic or biochemical parameters that provide insight into understanding disease processes and ways that medicines can work to counteract the disease.  With them, diseases are detected earlier, more effective treatments can be delivered, drug reactions reduced.  An example is creatine kinase, or CK-MB, a marker that facilitates high-energy phosphates in the body’s tissues, and can suggest a cardiovascular event when levels are high.  Other markers can identify the seriousness of tumors or signal immune system problems.

These biomarkers are valuable in assessing risk, detecting current disorders or diseases, treatment assessments, drug matching, etc. In research, biomarkers are useful for drug development and determining new markers for drug targeting.

The report will provide a market analysis for five broad areas of medical biomarkers:

    • The Market for Cancer Biomarkers (by Type of Cancer)


    • The Market for Cardiovascular and Blood Biomarkers


    • The Market for Endocrine and Immune Biomarkers


    • The Market for Infectious Disease Biomarkers (by Disease)


  • The Market for Neurological Disease Biomarkers

For each area, additional market detail is provided:

    • Segment Breakouts


    • Regional Breakout (US, EMEA, Other)


  • Market Share

Market analysis in this report considers both the epidemiological considerations and the size patient groups, available biomarkers in each segment, and estimated percentage of biomarker use in patient treatment.

The analysis presented in this report is based on data from a combination of company, government, industry, institutional and private sources. It includes information from extensive literature reviews and discussions with experts in the field, including microbiologists, pathologists, hospital authorities, reimbursement specialists, research scientists, business development managers and marketing managers.

All market data are based on factory sales to the end user and not retail pricing or reimbursement payments. Market data pertains to the world market at the manufacturers’ level. The base year for data was 2013. Historical data was provided for the years 2008 through 2012, with forecast data provided for 2014 through 2018. Compound annual growth rates (CAGRs) are provided for the 2008-2013 and 2013-2018 periods for each segment covered.

Basic competitor summaries are included in each segment. The forecasted market analysis for 2014-2018 was largely based on demographic trends, new developments, biomarker development, company performance trends, merger and acquisitions, and global expansion.

Company profiles in this report include:

    • 20/20 GeneSystems


    • Abbott Laboratories


    • Affymetrix


    • Agendia


    • Alere


    • Beckman Coulter


    • Becton Dickinson


    • Biocartis SA


    • Biodesix


    • bioMerieux


    • BioReference Laboratory


    • bioTheranostics


    • CardioDX


    • Celera Alameda


    • Clarient


    • deCODE Genetics


    • DiaGenic


    • Genomic Health


    • Genoptix Medical Laboratory


    • Illumina


    • Johnson & Johnson


    • Life Techologies


    • Memory Dx


    • Myriad Genetics


    • Nanostring Technologies


    • OPKO Health


    • Provista Dx


    • Qiagen


    • Roche


    • Seimens Healthcare


    • Singulex


    • Tethys Bioscience


  • Thermo Fisher Scientific

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

Overview

Scope and Methodology

Total Size and Growth of the Market

Issues and Trends Affecting Market

Leading Competitors

CHAPTER TWO: INTRODUCTION TO THE MEDICAL BIOMARKERS INDUSTRY

Overview

Types of Biomarkers

History and Definition of Biomarkers in Medicine

Personalized Medicine

Potential Benefits

Privacy and Public Perception

Biomarkers as Risk Assessment Tool

Biomarkers as Diagnostic Tool

Biomarkers as Screening Tool

Biomarkers as Treatment Selection Tool

Biomarkers as Therapy Monitoring Tool

Technologies

DNA Biomarkers

DNA Tumor Biomarkers

General Biomarkers

Protein Biomarkers

RNA Biomarkers

CHAPTER THREE: INDUSTRY TRENDS

The Health Industry

Population Demographics

Life Expectancy

Chronic Disease Impact

Disease and An Aging Population

Healthcare Reform in the United States

Antimicrobial Drug Resistance

BRIC Involvement

Regulatory Structure

Molecular Test Reimbursement

CHAPTER FOUR: BIOMARKERS IN CANCER

Overview

Biochemistry of Cancer Cells

Carcinogen Metabolism

Causes of Cancer Growth

Environmental Factors, DNA, RNA

Cellular Oncogenes

Tumor Suppressor Genes

History of Cancer

Cancer Types

Biomarker Examples

New Developments

Total Market Size and Forecast

Cancer Biomarker Market by Geographical Region

Competitor Summary

CHAPTER FIVE: BIOMARKERS IN CARDIOVASCULAR DISEASE AND BLOOD DISORDERS

Overview

The Cardiovascular System

Heart

Circulatory System

Cardiac Cycle

Coronary Circulation

Cardiac Myocytes

Molecular Contraction

Cardiovascular And Blood Diseases

Ischemic Heart Disease

Etiology

Pathophysiology

Atherosclerosis

Angina Pectoris

Acute Ischemia and Myocardial Infarction Chronic

Chronic Ischemic Cardiomyopathy

Sudden Cardiac Death

Valvular and Endocardial Diseases

Mitral Valve Disorders

Aortic Valve Disorders

Rheumatic Heart Disease

Endocarditis

Pericardial Diseases

Pericardial Effusion

Pericarditis

Myocardial Diseases

Myocarditis

Cardiomyopathy

Congenital Heart Diseases

Atrial Septal Defect

Ventral Septal Defect

Pulmonary Stenosis

Aortic Stenosis

Coarctation of the Aorta

Patent Ductus Arteriosus

Truncus Arteriosus

Transposition of the Great Arteries

Tricuspid Atresia

Congestive Heart Failure

Etiology

Cardiac Dysrhythmias

Hypertension

Risk Factors

Effects of High Blood Pressure

Blood Disorders

Hyperlipidemia

Biomarker Availability

New Developments

Total Market Size and Forecast

Cardiovascular Disease and Blood Disorder Biomarker Market by Geographical Region

Competitor Summary

CHAPTER SIX: BIOMARKERS IN ENDOCRINE AND IMMUNE DISORDERS

Overview

The Endocrine System

Hormone Function

Hormone Synthesis

Immune System

Autoimmunity

Genetic Factors

Environmental Factors

Inflammatory Disorders

Disease Overview

Classification of Endocrine Disorders

Growth Hormone Disorders

Etiology of Growth Hormone

Antidiuretic Hormone Disorders

Etiology

Thyroid Hormone Disorders

Hypothyroidism

Hyperthyroidism

Adrenocortical Hormone Disorders

Diabetes Mellitus

Type 1 Diabetes

Type 2 Diabetes

Biomarker Availability

New Developments

Total Market Size and Forecast

Endocrine and Immune Disorder Biomarker Market by Geographical Region

Competitor Summary

CHAPTER SEVEN: BIOMARKERS IN INFECTIOUS DISEASE

Overview

Infection

Infectious Diseases

HIV Disease

Hepatitis C

Human Papillomavirus (HPV)

Sepsis

Biomarker Availability

New Developments

Total Market Size and Forecast

Infectious Disease Biomarker Market by Geographical Region

Competitor Summary

CHAPTER EIGHT: BIOMARKERS IN NERVOUS SYSTEM DISORDERS 167

Overview

The Nervous System

Central Nervous System

The Brain

Nervous System Disorders

Alzheimer’s Disease

Multiple Sclerosis

Parkinson’s Disease

Stroke

Biomarker Examples

New Developments

Total Market Size and Forecast

Nervous System Disorder Biomarker Market by Geographical Region

Competitor Summary

CHAPTER NINE: MARKET SUMMARY

Market Considerations

Market Overview

Medical Biomarkers Market by Application

Medical Biomarkers Market by Geographical Region

CHAPTER TEN: COMPANY PROFILES

Introduction

20/20 GeneSystems, Inc.

Company Overview

Abbott Laboratories

Company Overview

Affymetrix

Company Overview

Agendia, Inc. USA

Company Overview

Alere, Inc

Company Overview

Asuragen, Inc.

Company Overview

Beckman Coulter, Inc

Company Overview

Becton, Dickinson

Company Summary

Biocartis S.A.

Company Overview

Biodesix, Inc.

Company Overview

bioMerieux SA

BioReference Laboratories, Inc

Company Overview

biotheranostics, Inc.

Company Overview

CARDIODX, INC

Company Overview

CELERA ALAMEDA

Clarient, Inc

Company Overview

deCODE Genetics, Inc.

Company Overview

DiaGenic ASA

Company Overview

Genomic Health, Inc.

Company Overview

Genoptix Medical Laboratory

Company Overview

Illumina, Inc.

Company Overview

Johnson & Johnson

Company Overview

Life Technologies Corporation

Company Overview

Memory Dx

Company Overview

Myriad Genetics, Inc.

Company Overview

Nanostring Technologies, Inc.

Company Overview

OPKO Health, Inc.

Company Overview

Provista Dx

Company Overview

Qiagen N.V.

Company Overview

Roche

Company Overview

SIEMENS HEALTHCARE

Company Overview

Singulex, Inc

Company Overview

Tethys Bioscience

Company Overview

Thermo Fisher Scientific

Company Overview

APPENDIX: LIST OF CONTRIBUTORS

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1

The Global Medical Biomarker Market 2008-2018

Figure 1-1

The Global Medical Biomarker Market 2008-2018

Figure 1-2

The Global Medical Biomarker Market Estimated Market Share by Segment, 2013

CHAPTER TWO: INTRODUCTION TO THE MEDICAL BIOMARKERS INDUSTRY

Table 2-1

Differences Between DNA Biomarkers, DNA Tumor Biomarkers, and General Biomarkers

Table 2-2

Selected Biomarkers in Current Use

CHAPTER THREE: INDUSTRY TRENDS

Table 3-1

Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000 and 2011

Figure 3-1

Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000, and 2011

Table 3-2

Estimated World Population by Age and Geographical Region, 2012

Figure 3-2

Estimated World Population by Age and Geographical Region, 2012

Table 3-3

Average Life Expectancy in Years by Country 1980 and 2012

Figure 3-3

Average Life Expectancy in Years by Country 1980 and 2012

Table 3-4

Selected Disease Statistics, Worldwide, as at July 2012

Table 3-4

Elderly Support Ratio in Selected Countries (2050) (Note: Ratio is Number of 15 to 64 year olds for every 65+ year old.)

Table 3-5

Available Market Data, 2010

Table 3-6

BRIC Healthcare Infrastructure Capacity

CHAPTER FOUR: BIOMARKERS IN CANCER

Table 4-1

Viruses Associated with Cancer in Humans

Table 4-2

World Cancer Incidence by Selected Types of Cancer, 2010 and 2020, all races, both sexes

Figure 4-1

Estimated and Projected World Cancer Incidence by Selected Types of Cancer, 2010 and 2020

Table 4-3

Total Cancer Incidence by Sex and Country, 2010 Estimates

Figure 4-2

Total Cancer Incidence by Sex and Country, 2010 Estimates

Table 4-4

Selected Cancer Biomarkers in Development

Table 4-5

Global Cancer Biomarker Market 2008-2018

Figure 4-3

Global Cancer Biomarker Market 2008-2018

Figure 4-4

Global Cancer Biomarker Market by Application, Clinical versus Research 2008-2018

Figure 4-5

The Global Cancer Clinical Biomarker Market by Select Cancer Type, (Breast, Lung, Leukemia, Others) 2013

Figure 4-6

Global Cancer Biomarker Market Estimated Market Share by region (US, EMEA, Other), 2013

Figure 4-7

Global Cancer Biomarker Market Leading Suppliers, Estimates for 2013

CHAPTER FIVE: BIOMARKERS IN CARDIOVASCULAR DISEASE AND BLOOD DISORDERS

Table 5-1

Selected Cardiac Markers in Development

Table 5-2

Global Cardiovascular and Blood Disorder Biomarker Market 2008-2018

Figure 5-1

Global Cardiovascular and Blood Disorder Biomarker Market 2008-2018

Figure 5-2

Global Cardiovascular and Blood Disorder Biomarker Market by Application, Clinical versus Research 2008-2018

Figure 5-3

The Global Cardiovascular and Blood Disorder Clinical Biomarker Market by Select Disorder/Disease, 2013 (Cardiac, Blood, Other)

Figure 5-4

Global Cardiovascular and Blood Disorder Biomarker Market Estimated Market Share by region (US, EMEA, Other), 2013

Figure 5-5

Global Cardiovascular Disease and Blood Disorder Biomarker Market, Leading Suppliers Estimates for 2013

CHAPTER SIX: BIOMARKERS IN ENDOCRINE AND IMMUNE DISORDERS

Table 6-1

Selected Endocrine, Autoimmune, Inflammatory and Other Markers in Development

Table 6-2

Global Endocrine and Immune Disorder Biomarker Market 2008-2018

Figure 6-1

Global Endocrine and Immune Disorder Biomarker Market 2008-2018

Figure 6-2

Global Endocrine and Immune Disorder Biomarker Market by Application, Clinical versus Research 2008-2018

Figure 6-3

The Global Endocrine and Immune Disorder Clinical Biomarker Market by Select Disorder/Disease, 2013

Figure 6-4

Global Endocrine and Immune Disorder Biomarker Market Estimated Market Share by region (US, EMEA, Other), 2013

CHAPTER SEVEN :BIOMARKERS IN INFECTIOUS DISEASE

Table 7-1

Selected Infectious Disease Markers in Development

Table 7-2

Global Infectious Disease Biomarker Market 2008-2018

Figure 7-1

Global Infectious Disease Biomarker Market 2008-2018

Figure 7-2

Global Infectious Disease Biomarker Market by Application, Clinical versus Research 2008-2018161

Figure 7-3

The Global Infectious Disease Clinical Biomarker Market by Select Disorder/Disease, 2013

Figure 7-4

Global Infectious Disease Biomarker Market Estimated Market Share by region (US, EMEA, Other), 2013

Figure 7-5

Global Infectious Disease Biomarker Market, Leading Suppliers Estimates for 2013

CHAPTER EIGHT: BIOMARKERS IN NERVOUS SYSTEM DISORDERS

Table 8-1

Selected Neurological Disease Markers in Development

Table 8-2

Global Nervous System Disorder Biomarker Market 2008-2018 (Infection, Nervous System, Cancer, Cardiovascular/Blood, Endocrine/Immune)

Figure 8-1

Global Nervous System Disorder Biomarker Market 2008-2018

Figure 8-2

Global Nervous System Disorder Biomarker Market by Application, Clinical versus Research 2008- 2018

Figure 8-3

Global Nervous System Disorder Biomarker Market Estimated Market Share by region (US, EMEA, Other), 2013

CHAPTER NINE: MARKET SUMMARY

Table 9-1

The Global Medical Biomarker Market 2008-2018

Figure 9-1

The Global Medical Biomarker Market 2008-2018

Figure 9-2

The Global Medical Biomarker Market Estimated Market Share by Segment, 2013

Figure 9-3

The Global Medical Biomarker Market Estimated Market Share by Application, 2013

Figure 9-4

Global Medical Biomarker Market by Application, Clinical versus Research 2008-2018

Figure 9-5

The Global Medical Biomarker Market Estimated Market Share by Geographic Region, 2013

COMPANY PROFILES

LIST OF CONTRIBUTORS

 

    The Worldwide Market for Mass Spectrometry in Clinical Labs, 2024
    September 11, 2024
    Worldwide Sequencer Market, 2023-2028
    August 8, 2024
    The Worldwide Market for Liquid Biopsy, 6th Edition
    December 29, 2023
    The Market for RNA Sequencing, 3rd Edition
    September 8, 2023

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