Table of Contents

CHAPTER ONE: Executive Summary

• Overview
• Objectives, Scope, and Methodology
• Summary Of Findings
  • Overview of Current Market Dynamics
  • Refractive Vision Correction
  • Observations and Recommendations
  • Market Analysis and Forecasts
  • Major Eye Diseases
  • Observations and Recommendations
  • Market Analysis and Forecast
• Recent Market Events
  • Refractive Vision Correction
  • Technology
  • Business & Markets
  • Major Eye Diseases
  • Technology
  • Business & Markets

Chapter Two: The Dynamics of Change

• Business Issues
  • No Longer Business as Usual
  • Resistance to Change
• The New Technological Revolution
  • Competition Old vs New
  • Rushing to Development vs the Risk of Obsolescense
  • Refractive Vision Correction [RVC]
  • Major Eye Diseases
• Regulation
  • Government’s Role as Overseer
  • Government Mandate: Safety & Effectiveness
  • Developed & Underdeveloped Countries
  • Off-Label Use
  • Ophthalmologists vs Optometrists
  • Business Challenges in a Regulated Environment
  • Intellectual Property, Asset Ownership
  • International Trade [Export / Import]
  • Governance in a Publicly-Owned Company

Chapter Three: Restoration of Impaired Vision

• Treatment of Leading Vision Disorders
  • Conventional Eye Glasses and Contact Lens
  • Conventional Eye Glasses
  • Traditional Contact Lenses
  • Alternative Surgical Modalities
  • LASIK / Laser Surgery Intervention
  • RF Conductive Keratoplasty [RFK]
  • Other Innovative Treatment Options
  • Correctable Vision Implants—Spacers/Inserts
  • Temporary Correctable Vision Lenses
  • Lens Implants—Phakic & Implantable Lens Implants [ICL]
• Challenges & Threats in the Global Marketplace

Chapter Four: Vision Impacted by Disease

• Overview
• Cataracts
• Glaucoma
• Macular Degeneration
• Vitreoretinal Disorders
  • Diabetic Retinopathy [DR]
  • Diabetic Macular Edema [DME]
  • Retinal Detachment [RD]

Chapter Five: Refractive Vision Correction: Products and Technologies

• Competing Treatment Technologies and Competitive Maneuvers
• Competitive Products, Technology, Applications & Market Status

Chapter Six: Major Eye Diseases

• Overview
• Summary of Competing Technologies
• Cataract
• Glaucoma
• Age-Related Macular Degeneration
• Vitreoretinal Conditions

Chapter Seven: Market Dynamics

• Description of the Market
  • Eye Care Challenges
  • The Aging Process and Complications of Chronic Conditions
• Technology Overcomes Obsolete Methodologies
  • Older Treatment Modalities
  • Advanced Treatment Modalities
• The Competitive Arena
  • Pressures Influencing Structural Changes
• Market Influences
  • The Total Market
  • Refractive Vision Correction
  • Eye Diseases

Chapter Eight: Growth Forecasts

Bases of Market Forecast Market Forecasts—Growth Rates

Chapter Nine: Refractive Vision Correction

• Market Analysis & Forecast
• Background
  • Eye Glasses & Contact Lenses
  • Prevention & Wellness
  • Laser Surgery & Other Corrective Alternatives
• Competitive Market & Forecast
  • Market Size and Market Share
  • Market Size, Share, and Procedure Forecasts
  • Major Markets Forecast—Service Providers

Chapter Ten: Major Eye Diseases: Market

• Analysis & Forecast
• Market Challenges
• Market Size and Share
• Market Size, Share And Procedure Forecasts
  • Overview
  • Cataract Surgery and IOL [Intraocular] Lens
  • Glaucoma Treatment and Management
  • VitreoRetinal—Conventional & Advanced Treatments
  • Major Markets Forecast—Service Providers

Chapter Eleven: Company Profiles, Abstracts, and Briefs

• Advanced Medical Optics, Inc
  • Business Overview
  • Products -Technology—Intellectual Assets
  • Analysis of Markets, Comments & Competitive Challenges
• Alcon Laboratories, Inc
  • Business Overview
  • Products -Technology- Intellectual Property
  • Analysis of Markets, Comments & Competitive Challenges
• Alimera Sciences, Inc. [Asi]
• Allergan, Inc
  • Business Overview
  • Products / Technology / Intellectual Property
  • Analysis of Markets; Comments & Competitive Challenges
• The Amacore Group, Inc [Formerly Eyecare International, Inc.]
• Anika Therapeutics, Inc
• Bausch & Lomb, Inc
  • Business Overview
  • Products / Technology / Intellectual Property
  • Analysis of Markets, Comments & Competitive Challenges
• The Cooper Companies, Inc. [Cooper Vision, Inc.]
  • Business Overview
  • Maarket Analysis – Comments – Challenges
• Coronado Industries, Inc Sub: Ophthalmic International [OI]
  • Business Overview
  • Market Analysis – Comments – Challenges
• Eyeonics, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• Eyetech Pharmaceuticals, Inc
  • Business Overview
  • Product-Technology-Intellectual Property
  • Analysis of Market- Comments – Challenges
• Genaera Corporation
  • Business Overview
  • Market Analysis – Comments – Challenges
• Genetech, Inc
  • Business Overview
  • Comments & Analysis
• Heidelberg Engineering, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• Insight Vision, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• Inspire Pharmaceuticals, Inc
  • Company Overview
  • Market Analysis – Comments – Challenges
• Intralase Corporation
  • Business Overview
  • Products—Technology—Intellectual Property
  • Analysis – Comments – Competitive Challenges
• Iridex Corportion
  • Business Overview
  • Market Analysis – Comments – Challenges
• Keravision, Inc
• Lasersight Incorporated
• LCA Vision Inc
• Light Sciences Corporation [LSC] Sub: Visient Therapeutics [VT]
• Lumenis, Inc
  • Business Overview
  • Products – Technology – Intellectual Property
  • Analysis – Comments – Challenges
• Miravant Medical Technologies
  • Business Overview
  • Market Analysis – Comments – Challenges
• Nidek Technologies
  • Business Overview
  • Products – Technology – Intellectual Property
  • Analysis – Comments – Challenges
• Novadaq Technologies, Inc
• Novamed, Inc
• Novartis Ophthalmics
  • Business Overview
  • Market Analysis – Comments – Challenges
• Novavision, Inc
• Occulogix, Inc.
• Ophtec U.S.A
  • Business Overview
  • Market Analysis – Comments – Challenges
• Paradigm Medical Industries, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• QLT Inc
  • Business Overview
  • Comments / Analysis
• Refocus Group Inc [RFI]
  • Business Overview
  • Market Analysis – Comments – Challenges
• Refractec, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• Regeneron Pharmaceuticals, Inc
• Solx, Inc
  • Company Overview
  • Market Analysis – Comments – Challenges
• STAAR Surgical Company
  • Business Overview:
  • Products / Technology / Intellectual Property:
  • Analysis, Comments & Competitive Challenges
• Surgilight, Inc
  • Business Overview
  • Market Analysis – Comments – Challenges
• Talia Technology U.S.A Inc
  • Business Overview
  • Comments & Analysis
• TLC Vision Corporation
• Unilens Corporation
• Vision Care Ophthalmic Technologies Inc
  • Business Overview
  • Comments & Analysis
• VISX, Inc
  • Business Overview
  • Products, Technology and Intellectual Property
  • Analysis of Markets, Comments & Competitive Challenges

Appendix A: Registered Trademarks & Trade Names in Refractive Vision Correction

Appendix B: Registered Trademarks & Trade Names in Major Eye Disease

Appendix C: Glossary and Abbreviations

Appendix D: Professional/Scientific Sources

Appendix E: News/Research Sources

Appendix F: U.S. Regulatory Authorities and Statutes

Appendix G: International Regulatory Authorities and Statutes

List of Exhibits

CHAPTER ONE: Executive Summary

• Table 1-1: RVC Surgery Market Summary Revenue Distribution by Condition Type and Geography (Myopia, Hyperopia, Presbyopia, and Astigmatism; U.S. vs Non-U.S.) Total Revenue by Geography (U.S. vs Non-U.S.) 2004-2008
• Table 1-2: Market Summary for Laser Systems, Services; Lens Implants Revenue Distribution by Type and Geography (Laser Systems, Services/Fees; Lens Implants; U.S. vs Non-U.S.) Total Revenue by Geography (U.S. vs Non-U.S.) 2004-2008
• Table 1-3: Market Summary for Major Eye Diseases Revenue Distribution by Disease Type and Geography (Cataracts, Glaucoma, and Vitreoretinal Conditions; U.S. vs Non-U.S.) Total Revenue by Geography (U.S. vs Non-U.S.) 2004-2008
• Table 1-4: Market Summary for Major Eye Disease Revenue Distribution by Major Market Segments and Geography (Ophthalmologist, Vision Care Centers, Optometrists; U.S. vs. Non-U.S.) Total Revenue by Geography (U.S. vs. Non-U.S.) 2004-2008

Chapter Three: Restoration of Impaired Vision

• Exhibit 3-1: Primary Visual Aquity Conditions and Refractive Vision Correction Treatment Options

Chapter Four: Vision Impacted by Disease

• Exhibit 4-1: Diagnostics & Treatment Modalities for the Management of Eye Diseases

Chapter Five: Refractive Vision Correction: Products and Technologies

• Exhibit 5-1: Refractive vision correction Competitive Products, Technology, Application, Market Status

Chapter Six: Major Eye Diseases

• Exhibit 6-1: Major Eye Diseases Competitive Products, Technology, Application, Market Status
• Exhibit 6-2: Old Technology vs New Technology in the Management of Major Eye Disease

Chapter Eight: Growth Forecasts

• Exhibit 8-1: Growth Rates for Ophthalmology Segments, 2004-2005, 2006-2007, 2008 [RVC Products by Type, RVC Procedures by Type, Eye Disease Treatments/Diagnostics by Disease and Type, and Service Segments by Type]
• Exhibit 8-2: Growth Rates for Ophthalmology Companies, 2004-2005, 2006-2007, 2008 [44 Companies]

Chapter Nine: Refractive Vision Correction Market Analysis & Forecast

• Exhibit 9-1A: Refractive Vision Correction Market: Supplier Revenues and Market Share by Geography (U.S. vs Global) and Type (Laser Systems and Services) 2004
• Exhibit 9-1B: Refractive Vision Correction Market: Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Type (Laser Systems [LASIK Flap Devices, Other RVC], Lens Implant, Services/Fees) 2004
• Exhibit 9-1C: Refractive Vision Correction Market: Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Condition Treated (Myopia, Hyperopia, Presbyopia, Astigmatism) 2004
• Exhibit 9-2A: Refractive Vision Correction Market Forecast Market Size (U.S. vs Non-U.S.) by Type (Products and Services vs Lens Implants) and Supplier Revenues and Market Share in the United States 2005-2008
• Exhibit 9-2B: Refractive Vision Correction Market Forecast: Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Type (Laser Systems [LASIK Flap Devices, Other RVC], Lens Implant, Services/Fees) 2005-2008
• Exhibit 9-2C: Refractive Vision Correction Market Forecast: Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Condition Treated (Myopia, Hyperopia, Presbyopia, Astigmatism) 2005-2008
• Exhibit 9-2D: Refractive Vision Correction Lens Implants Market Forecast: Supplier Revenues and Market Share by Geography (U.S. vs Non-U.S.) 2005-2008
• Exhibit 9-3A: Refractive Vision Correction Procedure Forecast Market Size (U.S. vs Non-U.S.) by Type (Products and Services vs Lens Implants) and Supplier Revenues and Market Share in the United States 2004-2008
• Exhibit 9-3B: Refractive Vision Correction Lens Implants Procedure Forecast: Number of Procedures by Supplier by Geography (U.S. vs Non-U.S.) 2004-2008
• Exhibit 9-3C: Refractive Vision Correction Procedures Forecast: Number of Procedures by Geography (U.S. vs Non-U.S.) and Type (Laser Systems [LASIK Flap Devices, Other RVC], Lens Implant, Services/Fees) 2005-2008
• Exhibit 9-3D: Refractive Vision Correction Procedures Forecast: Number of Procedures by Geography (U.S. vs Non-U.S.) and Condition Treated (Myopia, Hyperopia, Presbyopia, Astigmatism) 2005-2008
• Exhibit 9-4A: Refractive Vision Correction Market Forecast: U.S. Service Provider Revenues and Market Share by Type (Laser/LASIK, Services and Fees, Lens Implants) and by Type of Provider (Ophthalmologists, Optometrists, Vision Care Centers, Eye Clinics, and Others) 2005-2008
• Exhibit 9-4B: Refractive Vision Correction Forecast: U.S. Market Share by Service Type (Laser/LASIK, Visual Acuity Exams, Services and Fees, Lens Implants) by Type of Provider (Ophthalmologists, Vision Care Centers, and Others) 2005-2008

Chapter Ten: Major Eye Diseases: Market Analysis & Forecast

• Exhibit 10-1: Major Eye Disease Market: Supplier Revenues and Market Share by Geography (U.S. vs Global) and Condition (Cataract, Glaucoma, Vitreoretinal) 2004
• Exhibit 10-1B: Major Eye Disease Market: Revenues and Market Share by Geography (U.S. vs Global) and Condition (Cataract, Glaucoma, Vitreoretinal) and Treatment Modality (Surgery vs IOL) 2004
• Exhibit 10-2: The Cataract Market: Supplier Revenues and Market Share by Geography (U.S. vs Global) and Treatment Modality (Surgery vs IOL) 2004
• Exhibit 10-3: The Glaucoma Market: Supplier Revenues and Market Share by Geography (U.S. vs Global) and Treatment Modality (Pharmaceuticals vs Other Treatment/Diagnostics) 2004
• Exhibit 10-4: The Vitreoretinal Disorder Market: Supplier Revenues and Market Share by Geography (U.S. vs Global) and Condition (AMD vs Other [Diabetic Retinopathy, Diabetic Macular Edema, Retinal Detatchment]) 2004
• Exhibit 10-5A: Major Eye Disease Market Forecast Supplier Revenues and Market Share Globally (2004) and in the United States (2005-2008)
• Exhibit 10-5B: Major Eye Disease Market Forecast Revenues and Market Share by Disease Type (Cataract, Glaucoma, Retinal Disorders) and Treatment Type Globally (2004) and in the United States (2005-2008)
• Exhibit 10-6: Major Eye Disease Treatment Procedure Forecast: Number of Procedures by Geography (U.S. vs Non-U.S.) and by Condition (Cataract, Glaucoma, AMD, Other Retinal Disorders) 2004-2008
• Exhibit 10-7: Cataract Market Forecast Supplier Revenues and Market Share Globally (2004) and in the United States (2005-2008) and Revenue Forecast (2005-2008) by Product Type (Surgery vs IOL), 2005-2008
• Exhibit 10-8: Glaucoma Market Forecast Supplier Revenues and Market Share Globally (2004) and in the United States (2005-2008) and Revenue Forecast (2005-2008) by Product Type (Pharma vs Other Tx/Dx), 2005-2008
• Exhibit 10-9: Vitreoretinal Market Forecast Supplier Revenues and Market Share Globally (2004) and in the United States (2005-2008) and Revenue Forecast (2005-2008) by Condition Type (AMD vs Other [Diabetic Retinopathy, Diabetic Macular Edema, Retinal Detatchment]), 2005-2008
• Exhibit 10-10: Major Eye Disease Market Forecast: U.S. Service Provider Revenues and Market Share by Type (Pharmaceuticals, Surgery, Dx Exam, IOL) and by Type of Provider (Ophthalmologists, Optometrists, Vision Care Centers, Eye Clinics, and Others) 2005-2008