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Cell Culture: The Market for Media, Sera and Reagents

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SKU: KLI5569984 Category: Biotechnology Market Research Pages: 170
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Description

Cell Culture: The Market for Media, Sera and Reagents

The growth in biopharmaceuticals is creating an unprecedented increase in demand for cell culture products. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques.  This Kalorama Information report, Cell Culture; The Market for Media, Sera and Reagents, analyzes the world market for media, sera and reagents and the major trends and drivers.  Authored by Anne Anscomb, it is the fifth time Kalorama Information has looked at this market since 2007.

As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals. The report contains market size projections, product offerings of major companies, current culture practice trends and company market share. The report focuses on three segments of the cell culture market

Media Market

Different kinds of cells require different types of media. Serum based media are widely used to grow a broad range of animal cell types and cell lines such as Chinese hamster ovaries (CHO) or murine myeloma cells (NS0) cells.  This report provides market size and forecast to 2019 for the following categories of media:

  • Animal-Free Media
  • Serum-Free Media
  • Chemically Defined Media

Sera Market

Serum has traditionally been used as the major supplement to cell culture media. Serum is a complex mix of albumins, growth factors and growth inhibitors. Serum is one of the most important components of cell culture media and serves as a source for amino acids, proteins, vitamins (particularly fat-soluble vitamins such as A, D, E, and K), carbohydrates, lipids, hormones, growth factors, minerals, and trace elements. This report provides market size and forecast to 2019 for the following categories of sera:

  • Newborn Calf
  • Other Bovine
  • Fetal Bovine Serum
  • Other Sera

Reagents Market

Cultured cells require a sterile environment and a supply of nutrients for growth. An alternative to purchasing prepared defined media, is to purchase reagents and other cell culture components to create an optimum environment for a particular cell line. Biological reagents are an intrinsic component in every research laboratory and research project. This report provides market size and forecast to 2019 for the following categories of reagents:

  • Buffers and Salt Solution
  • Cytokines and Growth Factors
  • Cell Dissociation Reagents
  • Others

Eleven cell culture-derived biopharmaceutical drugs were launched in the US and European markets in 2014. Biopharmaceuticals (recombinant proteins, monoclonal antibody and nucleic acid-based products) represent the fastest growing sector in the pharmaceutical industry. Driving the extraordinary interest in biopharmaceuticals is the ability of these large proteins to target diseases in a very specific manner, thus maximizing efficacy while minimizing side effects. The report discusses key market drivers and restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production. It also discusses late-breaking trends such as 3D cell Culture. In addition, the report reviews the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems.

Country Cell Culture Markets

A global report, market estimates for the overall cell culture market are segmented by geography. The report offers the following regions/countries:

  • North America
  • UK/Ireland
  • Rest of Europe
  • Asia
  • China
  • Japan
  • Singapore/Malaysia
  • Rest of World

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.

 Companies Profiled in This Report Include:
Advanced Biotechnologies, Inc.
Affymetrix, Inc.
AMRESCO, Inc.
Analytical Biological Services Inc.
Atlanta Biologicals, Inc.
Athena Enzyme Systems
BD Biosciences
Bioreclamation Inc
Cell Essentials, Inc.
CellGenix Technologie Transfer GmbH
ClonTech Laboratories, inc.
Corning Life Sciences
EMD Millipore
GE Healthcare Life Sciences
Gemini Bio-Products
invitria
Irvine Scientific
J R Scientific, Inc.
Life Technologies
Lonza Bioscience
MP Biomedicals
Novozymes Biopharma US Inc
PromoCell GmbH
Quality Biological, Inc.
SBH Sciences
Selexis SA
SeraCare Life Sciences, Inc.
Sera Laboratories International  Ltd
Sigma-Aldrich
Stemcell Technologies Inc.
Thermo Fisher Scientific, Inc.
Tico Europe
Wisent Bioproducts

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

Scope and Methodology

Cells for Biopharmaceutical Production

Bacteria and Yeasts Systems

Animal Cell Systems

Insect Cell Systems

Cell Lines and Cell Banks

Fermentors and Bioreactors

Stirred-tank Reactors

Airlift Fermentors

Packed Bed Reactors

Hollow-fiber Reactor

Single-use Disposable Systems

Perfusion Bioreactor

Fermentation Processes

Batch and Fed-Batch Fermentation

Suspended vs. Anchored Cells

Microencapsulation

Advancement In Cell Culture Techniques: 3d Cell Culture

Growing cells in three dimensional systems

Cell Culture Environment

Functions and Components of Basal Media

pH and Osmotic Pressure

Energy Sources

Nutrients

Cell Culture Media

Lysogeny broth (LB)

Classical Media

Serum-free Media

Protein-free Media

Chemically Defined Media

Specialty Media

Sera

Reagents

Shifting Towards Non-animal Derived Reagents

Addressing Reagent Safety Issues

Global Cell Culture Market

Cell Culture Market and Forecast

Current and Future Trends

CHAPTER TWO: INTRODUCTION

Growing Demand for Biopharmaceuticals

Biopharmaceutical Growth Increases Demand for Cell Culture Products

A Brief History of Biotechnology

Science of Genetic Manipulation

Biopharmaceutical Market and Production

Biopharmaceutical Production

Top Selling Biopharmaceuticals in 2012, 2013 and 2014

FDA-approved Biopharmaceuticals

Upstream Bioprocessing: Cell Culture Expression Systems

Cells for Biopharmaceutical Production

Bacteria and Yeasts Systems

Animal Cell Systems

Insect Cell Systems

Advantages/Disadvantages of Cell Culture Systems

Cell Lines and Cell Banks

Biopharmaceuticals Produced from Cell Culture

Cell Culture Practices/Guidelines

Validation of Facilities

Maintaining Sterilization Standards

CHAPTER THREE: TECHNOLOGY

Introduction and Overview

Milestones in Cell Culture Development

Cell Lines for Bioproduction

Predominant Cell Lines

Chinese Hamster Ovary (CHO)

SP2/0, and NS0

HEK 293 and PER. C6

Sources: Largest Collections of Cell Lines

Bioreactors

Types of Bioreactors/Fermentors

Stirred-tank Reactors

Airlift Fermentors

Packed Bed Reactors

Hollow-fiber Reactor

Single-use/Disposable Systems

Perfusion Bioreactor

Fermentation Processes

Batch and Fed-Batch Fermentation

Suspended vs. Anchored Cells

Microencapsulation

Advancement In Cell Culture Techniques: 3d Cell Culture

Growing Cells in Three Dimensional Systems

Functions and Components of Basal Media

pH and Osmotic Pressure

Energy Sources

Nutrients

Cell Culture Media

Types of Media

Lysogeny broth (LB)

Classical Media

Serum-free Media

Protein-free Media

Chemically Defined Media

Specialty Media

Sera

Sources of Sera

Bovine Serum Safety Issues and Regulations

Shift to Serum-free Media

Reagents

Major Types of Biologic Reagents

Amino Acids

Growth Factors and Cytokines

Albumin

Transferrin

Thrombin

Growth Supplements

Protease Inhibitor

Attachment Factors

Shifting Towards Non-animal Derived Reagents

Addressing Reagent Safety Issues

CHAPTER FOUR: CELL CULTURE MARKET

Overview

Cell Culture Market

Market Drivers

Cell Culture Market Forecast

Global Cell Culture Market Share, by Region

Global Market Share, by Region, 2014 and 2019

Asia Pacific Region Gaining Market Share

Singapore: Fastest Growing Region

Market Segment Analysis

Media

Percentage of Market by Media Type

Advantages and Disadvantages of Using Serum

Liquid Versus Powdered Media

Sera

Reagents

Reagent Types

Cytokines and growth factors

Cell Dissociation Reagents

Buffers and Salt Solutions

Other Reagents

Cell Culture Supplier Market Share

Market Leaders in Cell Culture, 2014

Current and Future rends

Shift to Serum-free and Animal Product-free Media

Cell Culture-based Vaccine Production

Cell Culture-based Seasonal Vaccines

Stem Cell Research Driving Cell Culture Market

Sigma-Aldrich

ThermoFisher Scientific

Lonza Bioscience

EMD Millipore

BD Bioscience

Impact of Generic Biopharmaceuticals on Cell Culture Market

CHAPTER FIVE: COMPANY PROFILES

Advanced Biotechnologies, Inc.

History and Lines of Business

Cell Culture Products and Services

Affymetrix, Inc

History and Lines of Business

Cell Culture Products, Reagents and Biochemicals

AMRESCO, Inc.

History and Lines of Business

Cell Culture Products

Analytical Biological Services Inc.

History and Lines of Business

Cell Culture Products

Atlanta Biologicals, Inc.

History and Lines of Business

Cell Culture Products

Athena Enzyme Systems

History and Lines of Business

Cell Culture Products

BD Biosciences

History and Lines of Business

Cell Culture Products

Bioreclamation Inc

History and Lines of Business

Cell Culture Products

Cell Essentials, Inc.

History and Lines of Business

Cell Culture Products

CellGenix Technologie Transfer GmbH

History and Lines of Business

Cell Culture Products and Services

ClonTech Laboratories, inc.

History and Lines of Business

Cell Culture Products

Corning Life Sciences

History and Lines of Business

Cell Culture Products

EMD Millipore

History and Lines of Business

Cell Culture Products

GE Heathcare Live Sciences

History and Lines of Business

Cell Culture Products

Gemini Bio-Products

History and Lines of Business

Cell Culture Products

invitria

History and Lines of Business

Cell Culture Products

Irvine Scientific

History and Lines of Business

Cell Culture Products

J R Scientific, Inc.

History and Development

Cell Culture Products

Life Technologies

History and Lines of Business

Cell Culture Products

Lonza Bioscience

History and Lines of Business

Cell Culture Products and Services

MP Biomedicals

History and Lines of Business

Cell Culture Products

Novozymes Biopharma US Inc

History and Lines of Business

Cell Culture Products

PromoCell GmbH

History and Lines of Business

Cell Culture Products

Quality Biological, Inc.

History and Lines of Business

Cell Culture Products

R&D Systems, Inc

History and Lines of Business

Cell Culture Products

SBH Sciences

History and Lines of Business

Cell Culture Products

Selexis SA

History and Lines of Business

Cell Culture Products and Technology

SeraCare Life Sciences, Inc.

History and Lines of Business

Cell Culture Products

Sera Laboratories International Ltd

History and Lines of Business

Cell Culture Products

Product Categories

Sigma-Aldrich

History and Lines of Business

Cell Culture Products

Stemcell Technologies Inc.

History and Lines of Business

Cell Culture Products

Thermo Fisher Scientific, Inc.

History and Lines of Business

Cell Culture Products

Tico Europe

History and Lines of Business

Cell Culture Products

Wisent Bioproducts

History and Lines of Business

Cell Culture Products

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Exhibit 1-1: Global Cell Culture Market, 2009-2019

Exhibit 1-2: Cell Culture Global Market Share, 2014 (North America, UK/Ireland, Rest of Europe,

China, Japan, Korea, Singapore/Malaysia, ROW)

CHAPTER TWO: INTRODUCTION

Exhibit 2-1: Top Selling Biological Drugs in 2012 and 2013

Exhibit 2-2: Top Selling Biological Drugs in 2014

Exhibit 2-3: FDA Biopharmaceutical Product Approvals, 2013

Exhibit 2-4: FDA Biopharmaceutical Product Approvals, 2014

Exhibit 2-5: Approximate times from Introduced Gene to Protein Production at Useable Levels

Exhibit 2-6: Disadvantages/Advantages of Cell Culture Systems

Exhibit 2-7: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells

CHAPTER THREE: TECHNOLOGY

Table 3-1: Five Types of 3D Cell Culture Methods

Exhibit 3-2: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma,Myeloma and CHO cell lines

CHAPTER FOUR: MARKET ANALYSIS

Exhibit 4-1: Global Cell Culture Market, 2009-2019

Exhibit 4-2: Cell Culture Global Market Share, by Region, 2014 (North America, UK/Ireland, Rest of

Europe, China, Japan, Korea, Singapore/Malaysia, ROW)

Exhibit 4-3: Cell Culture Global Market Share, by Region, 2019

Exhibit 4-4: Global Market Share, 2014 and 2019

Exhibit 4-5: Global Cell Culture Market by Segment Media, Sera and Reagents, 2009-2019

Exhibit 4-6 Media Sales, 2014-2019

Exhibit 4-7 Market Share, by Media Type, 2014 (Animal-Free, Serum-Free, Chemically Defined)

Exhibit 4-8: Market Share, by Media Type, 2019 (Animal-Free, Serum-Free, Chemically Defined)

Exhibit 4-10: Sera Sales, 2009-2019

Exhibit 4-11: Market Share by 2014 by Sera Type(Newborn Calf, Other Bovine, Other Sera, Fetal Bovine Serum)

Exhibit 4-12: Reagent Sales, 2009-2019

Table 4-13: Market Share by Reagent Type, 2014 (Buffers and Salt Solution, Cytokines and Growth Factors, Cell Dissociation Reagents, Buffers and Salt Solutions, Others)

Exhibit 4-14: Cell Culture Company Market Share 2014

 

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