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Cell Culture: The World Market for Media, Sera and Reagents, 2nd Edition

$2,995.00 – $7,990.00

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SKU: KLI2091313 Categories: Biopharmaceuticals Market Reports, Biotechnology Market Research, Proteomics Pages: 145
  • Description
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Description

Cell culture is a major foundation of biopharmaceutical development, bioprocessing and manufacturing. As the biopharmaceutical market grows, so should interest in the cell culture products market. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques. As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals.

This report, Cell Culture represents the second time that Kalorama has focused on culture used in the research and production of biopharmaceuticals, analyzing the world cell culture market and the major trends driving this market in three specific segments:

  • Media,
  • Sera, and
  • Reagents

 

In addition to a thorough discussion of the technologies and techniques currently employed and emerging in the cell culture area, the Kalorama’s exhaustive report provides specific information on:

  • Market Size, growth, and forecasts of the segments through 2013
  • Competitive Market Share by leading supplier as of 2008.
  • Estimated Market Share by Region (North America, Europe, U.S.)
  • Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production.
  • Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems
  • Discussion of the preferences in media types vying for dominance in the market, including the following:
    • ADCF – animal derived component free media
    • CD – chemically defined media
    • CSFM – complete serum free medium
    • PF – protein free media
    • SF – serum free media
    • SFM – serum free medium
  • Major Trends Impacting the Market stem cell research (including plans of major companies)cell culture-based vaccine Production and generic bipharmaceuticals
  • Profiles of 27 Leading Suppliers and information about M&A activities in recent years

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.

All Kalorama reports advertise the single user price, which limits access to one user. We also feature department and global pricing for reports that will be utilized by more than one user at your company. Please ask your sales representative or select the correct license on our website.

For Kalorama’s take on the healthcare news of the week, based on our analysis of healthcare markets, follow Kalorama Information’s Key Point Blog at http://kaloramakeypoint.blogspot.com/

Table of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

Scope and Methodology

Cells for Biopharmaceutical Production

Bacteria and Yeasts Systems

Animal Cell Systems

Insect Cell Systems

Cell Lines and Cell Banks

Fermentors and Bioreactors

Stirred-tank Reactors

Airlift Fermentors

Packed Bed Reactors

Hollow-fiber Reactor

Disposable Systems

Fermentation Processes

Batch and Fed-Batch Fermentation

Suspended vs. Anchored Cells

Microencapsulation

Cell Culture Environment

Functions and Components of Basal Media

pH and Osmotic Pressure

Energy Sources

Nutrients

Cell Culture Media

Lysogeny broth (LB)

Classical Media

Serum-free Media

Protein-free Media

Chemically Defined Media

Specialty Media

Sera

Reagents

Shifting Towards Non-animal Derived Reagents

Addressing Reagent Safety Issues

World Cell Culture Market

Impact of Shift to Serum-free Products on Cell Culture Suppliers

Impact of Shift to Serum-free Products on Research

Impact of Shift Serum-free Products on Biopharmaceutical Manufacturers

Cell Culture Market and Forecast

Trends Impacting The Cell Culture Market

 

CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT

Growing Demand for Biopharmaceuticals

Demand Increasing for Cell Culture Products

A Brief History of Biotechnology

Science of Genetic Manipulation

From Petri Dish to Biopharmaceutical

Upstream Bioprocessing: Cell Culture Expression Systems

Cells for Biopharmaceutical Production

Bacteria and Yeasts Systems

Animal Cell Systems

Insect Cell Systems

Advantages/Disadvantages of Cell Culture Systems

Cell Lines and Cell Banks

Biopharmaceuticals Produced from Cell Culture

Cell Culture Practices and Regulatory Guidelines

Validation of Facilities

Maintaining Sterilization Standards

 

CHAPTER THREE: CELL CULTURE TECHNOLOGY

Introduction and Overview

Milestones in Cell Culture Development

Cell Lines for Bioproduction

Predominant Cell Lines

Chinese Hamster Ovary (CHO)

SP2/0, and NS0

HEK 293 and PER. C6

Sources: Largest Collections of Cell Lines

Fermentors and Bioreactors

Types of Bioreactors/Fermentors

Stirred-tank Reactors

Airlift Fermentors

Packed Bed Reactors

Hollow-fiber Reactor

Disposable Systems

Fermentation Processes

Batch and Fed-Batch Fermentation

Suspended vs. Anchored Cells

Microencapsulation

Cell Culture Environment

Functions and Components of Basal Media

pH and Osmotic Pressure

Energy Sources

Nutrients

Cell Culture Media

Types of Media

Lysogeny broth (LB)

Classical Media

Serum-free Media

Protein-free Media

Chemically Defined Media

Specialty Media

Sera

Sources of Sera

Bovine Serum Safety Issues and Regulations

Shift to Serum-free Media

Reagents

Major Types of Biologic Reagents

Amino Acids

Growth Factors and Cytokines

Albumin

Transferrin

Thrombin

Growth Supplements

Protease Inhibitor

Attachment Factors

Shifting Towards Non-animal Derived Reagents

Addressing Reagent Safety Issues

 

CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS

Overview

Shift Away From Serum-Based Cell Culture

Impact of Shift to Serum-free Products on Cell Culture Suppliers

Impact of Shift to Serum-free Products on Research

Life Technologies’ End Run Around the BSE Issue

Cell Culture Market

Market Drivers

Cell Culture Market and Forecast

Segment Analysis

Media

Sera

Reagents

Market Characteristics

Market Share: Cell Culture Suppliers

Trends Impacting The Cell Culture Market

Stem Cell Research

Life Technologies

Sigma-Aldrich

Millipore Corporation

ThermoFisher Scientific

Lonza Bioscience

Cell Culture-based Vaccine Production

Generic Biopharmaceuticals

Transgenically Produced Biopharmaceuticals

 

CHAPTER FIVE: COMPANY PROFILES

Advanced Biotechnologies, Inc

History and Lines of Business

Cell Culture Products and Services

Amresco, Inc

History and Lines of Business

Cell Culture Products

Analytical Biological Services Inc

History and Lines of Business

Cell Culture Products

Mammalian Cell Culture

Cell in Microtiter Plates for HTS

Primary Cultures

Insect Cell Culture

Atlanta Biologicals, Inc

History and Lines of Business

Cell Culture Products

Athena Enzyme Services

History and Lines of Business

Cell Culture Products

BD Biosciences

History and Lines of Business

Cell Culture Products

Financial Information

Biochrom AG

History and Lines of Business

Cell Culture Products

Cell Essentials, Inc

History and Lines of Business

Cell Culture Products

CellGenix Technologie Transfer GmbH

History and Lines of Business

Cell Culture Products and Services

Irvine Scientific

History and Lines of Business

Cell Culture Products

J R Scientific, Inc

History and Development

Cell Culture Products

Life Technologies Corporation

History and Lines of Business

Cell Culture Products

Financial Information

Lonza Bioscience

History and Lines of Business

Cell Culture Products and Services

Culture Media Development

Cell Line Creation

Cell Banking

Financial Information

Mediatech, Inc

History and Lines of Business

Cell Culture Products

Millipore Corporation

History and Lines of Business

Cell Culture Products

Financial Information

MP Biomedicals

History and Lines of Business

Cell Culture Products

PAA laboratories, Inc

History and Lines of Business

Cell Culture Products

PromoCell GmbH

History and Lines of Business

Cell Culture Products

Quality Biological, Inc

History and Lines of Business

Cell Culture Products

R&D Systems, Inc

History and Lines of Business

Cell Culture Products

SBH Sciences

History and Lines of Business

Cell Culture Products

Selexis SA

History and Lines of Business

Cell Culture Products

SeraCare Life Sciences, Inc

History and Lines of Business

Cell Culture Products

Financial Information

Sigma-Aldrich Corporation

History and Lines of Business

Cell Culture Products

Financial Information

Thermo Fisher Scientific, Inc

History and Lines of Business

Cell Culture Products

Financial Information

USB Corporation

History and Lines of Business

Cell Culture Products

Wisent, Inc

History and Lines of Business

Cell Culture Products

APPENDIX: A: COMPANY DIRECTORY

APPENDIX: B: PROFESSIONAL ORGANIZATIONS

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Worldwide Cell Culture Market

Figure 1-1: Cell Culture World Market Share, by Region, 2008 (US, Asia/Pacific, EU)

CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT

Table 2-1: Biopharmaceuticals Approved in the USA and/or the EU in 2007

Table 2-2: Approximate times from Introduced Gene to Protein Production at Useable Levels

Table 2-3: Disadvantages/Advantages of Cell Culture Systems

Table 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells

CHAPTER THREE: CELL CULTURE TECHNOLOGY

Table 3-1: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma and CHO cell lines

CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS

Table 4-1: Selected Brandname Serum-Free Formulations of Cell Culture Products Currently on the Market

Table 4-2: Worldwide Cell Culture Market

Figure 4-1: Cell Culture World Market Share, by Region, 2008 (US, Asia, EU)

Table 4-3: World Cell Culture Market by Segment: Media, Sera and Reagents

Table 4-4: Cell Culture Market Share, 2008

 

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