Table of Contents

Chapter One: Executive Summary

• Market Definitions
• Commercialization Challenges
• Development Trends
• Optical Biosensor Innovations
• Microminiaturization of Sensors
• Summary and Comparison of Results

Chapter Two: Introduction

• Definitions and Categories
• Classification of Sensors Based on Analyte
• Classification by Measurement and Control
• Classification by Element and Operation
• Advantages of Biosensors

Chapter Three: Biosensor Technology

• General Biosensor Technology
  • Liquid Handling Systems
  • Signal Processing and Data Analysis
  • Potentiostats
  • Software for Biosensor Data Analysis
  • Spectroscopic Transduction
  • Fourier Transform Infrared Spectroscopy
  • Spectrophotometers for Sensor Applications
  • Infrared Reflectance Probes
• High-Tech Biosensors
  • Miniaturization of Sensors
  • Nanoparticle Sensors
  • Quantum Dots
  • Representative Current High-Tech Biosensor Development Projects
  • Smart Sensors
• Biochemical Recognition
  • Enzyme Biocatalysts-Based Biosensors
  • Enzyme Inhibition
  • Bioaffinity-Based Biosensors
  • Immunosensors
  • Microorganism-Based Biosensors
  • Oxygen Demand and Inhibition
  • Genetically Engineered Microorganisms
• Signal Transduction
  • Potentiometric Transducers
  • Amperometric Transducers
  • Conductance Measurements
  • Optical Measurements
  • Fluorescence
  • Protein Chip System
  • Surface Plasmon Resonance
  • Electrochemical Surface Plasmon Resonance (E-SPR)
  • SPR Biosensor: Tool for Real-time Analysis of Biomolecular Interactions
  • Sensitive Optical Detection
• Sensors Based on the Piezoelectric Effect
  • Introduction
• Acoustic Transducers
  • Surface Phenomena of Piezoelectric Materials
• Sensor Manufacturing Technologies
  • Microfluidics and LOC Technologies
  • Microelectronic Manufacturing Technologies
  • Monolithic Semiconductor Technologies
  • Lithography
  • Ceramic-Based Sensors
  • Polycrystalline and Vitreous Systems
  • Thin- and Thick-film Technologies
  • Evaporation and Sputtering
  • Processing Polymer Films
  • Photolithography
  • Electrically Active Polymers
  • Fiberoptic Technologies

Chapter Four: Biosensor Applications

• Biomedical Applications
  • Special Requirements
  • Medical Imaging
  • Clinical Diagnosis
  • Chemical and Biosensors for Clinical in Vivo Monitoring
  • Point of Care Biosensor Applications
  • Advances in Point-of-Care Testing
  • Future POCT Innovations
  • The Future of POCT
  • Non-Clinical Diagnostics
  • Molecular Diagnostics Clinical Tests and Clusters
  • Nanoscale Devices and Nanotechnologies
  • Nanotubes for Biological Sensors
• Foodborne Microbial Pathogen Detection
  • E. Coli O157:H7
  • Liposome-Based Bacteria Sensors
  • New Food Sensor Techniques
  • New Detection Methods Improve Food Safety
  • Monitoring Food for Residues
  • Detection of Pathogens and Toxins in Food
  • Detection of Listeria Pathogen
  • Market Restraints on Food Diagnostics
• Environmental Pollution and Hazard Monitoring
  • Monitoring for Toxic Industrial Materials
  • Future Directions
• Biowarfare and Bioterrorism
  • Bioterrorism Gets Our Attention
  • Requirements For Sensing Biological Weapons
  • Technologies for Bioagent Detection
  • Biosensors for Chemical Agents
• Industrial Process Control
  • World Process Analytical Instrumentation Market
  • Market Penetration into Nonmedical Applications

Chapter Five: The Biosensor Market

• Market Dynamics and Factors Effecting the Overall Segment
  • The Focus is on Development of Applications as well as Sensors
  • High Costs of Biosensor Development
  • Manufacturing and Product Problems
  • Biosensor Development Specialists Work Closely with Users
  • Technologies Synergistic with Biosensors are Maturing and Competing
  • Impact of Miniaturization and Nanotechnology
  • Rapid Development of Microarray Technology Encourages Investment
  • Need to Balance Fundamental Research and Application Development
  • Older Technologies are Difficult to Replace
  • Small Companies with Niche Markets verses Large Companies with Mass Markets
• Factors that are Expanding the Biosensor Market
  • Greater Expectations of Quality of Life
  • Innovative new Technologies and Applications
  • Collaboration among Industrial, Governmental, and Academic Laboratories
  • Growing Acceptance of Biosensor Methods
• Successful Biosensors
• Market Data

Chapter Six: Company Profiles

• Abbott Diabetes Care
• Abbott Laboratories
• ABTECH Scientific, Inc.
• Advanced Biosensor Inc.
• Affinity Sensors
• Affymetrix
• Agilent Technologies
• Akubio Ltd
• Alcove Surfaces GmbH
• Alnylam Pharmaceuticals
• Ambri Limited
• AMETEK Princeton Applied Research
• Antibodies Incorporated
• Applera Corporation
• Applied BioPhysics, Inc.
• Archemix Corp.
• BCR Diagnostics Inc.
• BD Biosciences
• Beckman Coulter
• Becton, Dickinson and Company
• Biacore International AB
• BioForce Nanosciences, Inc.
• Biophage Pharma, Inc.
• Biosite Incorporated
• Boston MicroSystems
• Bruker BioSciences Corporation
• Chemel AB
• Cholestech Corporation
• Ciphergen Biosystems
• CombiMatrix Corporation
• Cranfield University — Institute of BioScience and
• Technology
• Cytoplex Biosciences
• Dade Behring Holding Inc.
• Diagnostic Products Corporation
• Diversa Corporation
• DuPont Microcircuit Materials
• Endress+Hauser, Inc.
• Ercon, Inc.
• Evident Technologies
• Farfield Sensors Ltd Unit 51
• FIAlab Instruments, Inc
• HTS Biosystems Incorporated
• Human Genome Sciences
• i-STAT Corporation,
• Ibis Technology Corporation
• Infineon Technologies AG
• Invitrogen Corporation
• Isis Pharmaceuticals, Inc.
• Johns Hopkins University
• Johnson & Johnson
• Luna Analytics
• Matsushita Electric Industrial Co., Ltd.
• MicroFluidic Systems, Inc.
• MicroTEC Gesellschaft für Mikrotechnologie mbH
• Mitsubishi Electric Corporation
• Molecular Devices Corporation
• Molecular Probes, Inc.
• Nanotechnology Institute
• Neogen Corporation
• NeuroMetrix Inc.
• Nitrate Elimination Co., Inc. (NECi)
• Nomadics, Inc.
• Nova Biomedical
• PDSi Pinnacle
• Perkin Elmer
• Perlegen Sciences, Inc.
• PharmaNetics, Inc
• Prolinx, Inc.
• Qiagen
• QMED Inc.
• QTL Biosystems, LLC QTL Biosystems (UK) Ltd.
• Quantum Dot Corp.
• Rapid Biosensor Systems Ltd
• Reichert Analytical Instruments
• Roche Holding Ltd.
• Sensopath Technologies
• Sixth Sense
• Spacelabs Medical, Inc.
• Spectral Diagnostics Inc.
• SpectRx Inc.
• SRU Biosystems, Inc.
• Strategic Diagnostics Inc.
• Tetracore, Inc
• Thermo Electron Corporation
• Thermotron Industries
• Theron, Inc.
• ThreeFold Sensors
• Toshiba Medical Systems
• Transducer Technology, Inc.
• USAID Development Experience Clearinghouse
• XanTec bioanalytics GmbH
• Zyomyx, Inc.

Appendix A: Annotated List of Potentiostat

Manufacturers and Distributors

Appendix B: Ancillary Data Used to Support Market Assumptions

Appendix C: Selected Recent U.S. Patents on Biosensors

List of Exhibits

Chapter one: Executive Summary

• Exhibit 1: Summary: World Market for Biosensors 2004-2009

Chapter two: Introduction

• Exhibit 2: Summary of Common General Biosensor Applications
• Exhibit 3: General Classification of Technologies Used in the Design of Biosensors
• Exhibit 4: List of Specific Biosensor Applications
• Exhibit 5: Sensors Commonly Classified According to the Quantity That They Measure
• Exhibit 6: Important Applications of Biosensors
• Exhibit 7: General Types of Analyte-Bioreceptor Interactions
• Exhibit 8: Biochemical Recognition Molecules—Receptors
• Exhibit 9: Common Transducer Technologies Used in Biosensors Systems

Chapter Three: Biosensor Technology

• Exhibit 10: Commercialization Challenges for General Biosensors
• Exhibit 11: Summary of Selected Commercial Flow Analyzers (Manufacturer, Price, Applications, Flow Diameter/Sample Throughput, Sample Injection/Number/Volume, Detectors, Accessories)
• Exhibit 12: Examples of Sensor Functions Facilitated by Microprocessor and Memory Built into a Smart Sensor
• Exhibit 13: Some Examples of Biomolecular Interactions Which Have Been Successfully Studied Using SPR
• Exhibit 14: Classical Materials and Processing Technologies Used to Fabricate Biosensors
• Exhibit 15: Advantages and Disadvantages of Silicon-Based Sensor Production (Monolithic Semiconductor Processing)
• Exhibit 16: Advantages of Applying Thin and Thick Films in Sensor Fabrication
• Exhibit 17: Advantages and Disadvantages of Applying Polymer Films in Sensors
• Exhibit 18: Some Advantages and Disadvantages of Fiberoptic

Chapter Four: Biosensor Applications

• Exhibit 19: Number of Foodborne Disease Outbreaks and Cases by Etiology 2003 Summary Statistics
• Exhibit 20: Obstacles Common to All Commercially Viable Biosensors Used for Field Analytical Methods
• Exhibit 21: Important Factors in the Selection of Biosensors for Process Control Analyzers

Chapter Five: The Biosensor Market

• Exhibit 22: World Biosensor Market by Geographical Region/Country (North America, European Union, Japan, China, Latin America, India, Eastern Europe, Rest of World) 2004-2009
• Exhibit 23: World Biosensor Market by General Application (Research Laboratories, Medical Applications, Industrial Control, Biodefense, Environmental) 2004-2009
• Exhibit 24: The World Market for Biosensors for Medical Measurement Applications by Application (Blood Glucose, Coagulation Rate, Cholesterol, Others) 2004-2009
• Exhibit 25: The World Market for Biosensors for Industrial Process Control by Type (Alcohol/Beverages/Fuel, Sugars/Carbohydrates, Dairy Products, Meat Products, Others) 2004-2009

Appendix B: Ancillary Data Used to Support Market Assumptions

• Exhibit B-1: World Healthcare Expenditure (Government and Private) by Region, 2004-2009
• Exhibit B-2: World Markets for Bioanalytical Equipment by Type (Total Biohazard Diagnostics, Biochip Systems [LOC, Arrays], Protein Microarrays, and Total Analytical Microarrays), 2004-2009
• Exhibit B-3: Number of Biotech Companies by Region (North America, Europe, Asia/Pacific, Rest of World) 2004-2009