Description
For the past 60 years, antibiotic drugs have changed bacterial infections from the life-threatening scourges they once were into eminently treatable conditions. However, the effectiveness of many antibiotics is waning dramatically, as more and more types of bacteria become resistant to traditional agents. As a result, pharmaceutical companies are taking a second look at the antibiotic market, after more than two decades of relative complacency.
In addition to the scientific and technical challenges of new antibiotic development, there are significant business challenges, as well. The 2004 market for antibacterials actually posted a decline over 2003 and generic competition continues to threaten the anti-infective franchises of major manufacturers. Development cost for new anti-infectives have been shown to be higher than other therapeutic classes and political and economic pressures particular to anti-infective classes make recovering these costs challenging.
In this study, Kalorama Information segments the market for antibacterial medication into seven general categories based on drug class:
- cephalosporins
- macrolides
- penicillins
- quinolones
- sulfonamides
- tetracyclines
- other misc. antibiotics
For each segment, the report provides market size, growth, and share. The base year for data was 2004. Historical data are provided for the years 2002 and 2003, with forecast data provided for 2005 through 2009, based on probability of approval and sales of products in late stage development, product marketing, and demographic trends. Compound annual growth rates (CAGRs) are provided for the 2002-2004, 2004-2009 and 2002-2009 periods for each industry segment covered. Market shares by supplier, by infection type, and by top products are provided for the year 2004. Regional breakdowns in each segment are provided for the United States, Europe, Japan, and Rest of World for the entire forecast period. All market data are provided at the manufacturers’ level in constant U.S. dollars.
In addition to market data, the report includes statistical information on bacterial infections by type worldwide, with special emphasis on the U.S. market. The market segments provide an overview, description of products on the market, and a description of products in development. The report also includes current issues and trends affecting the industry, including:
- Antibiotic drug development and costs
- Drug resistance and interactions
- Antibiotic cycling
- Incentives to develop antibiotics
- Antibiotic use in agriculture
- Antibiotic education
- Special usage issues in pediatric and geriatric populations
- Immunocompromised individuals and resistance
- Antibiotics and atherosclerosis
The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and e-mail correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, health care providers, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company representatives included marketing directors, division managers, and product representatives.
Table of Contents
Chapter One: Executive Summary
- Introduction
- Scope and Methodology
- Size and Growth of the Market
- Issues and Trends Affecting Market
- Leading Competitors
Chapter Two: Introduction
- Bacterial Pathogens
- Classification of Bacterial Organisms
- Antibiotic Agents
- Spectrum of Activity
- Bacterial Resistance
- Principles of Anti-Infective Therapy
- Combination Therapy and Prophylactic Use
- Demographics and Epidemiology
Chapter Three: Issues and Trends
- Antibiotic Drug Development and Costs
- Drug Resistance and Interactions
- Antibiotic Cycling
- Addressing Resistance and Overuse
- Incentives to Develop Antibiotics
- Infectious Disease Society of America
- BioShield I, II
- Antibiotic Use in Agriculture
- Antibiotic Education
- Children and Bacterial Resistance
- The Elderly and Bacterial Resistance
- Immunocompromised Populations and Bacterial Resistance
- Antibiotic Use in Pediatric Asthma
- Screening Hospitalized Patients
- Antibiotics and Atherosclerosis
- Side Effects
Chapter Four: Cephalosporin Antibiotics
- Overview
- Description of Products
- First Generation Cephalosporins
- Second Generation Cephalosporins
- Third Generation Cephalosporins
- Fourth Generation Cephalosporins
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Five: Macrolide Antibiotics
- Overview
- Description of Products
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Six: Penicillin Antibiotics
- Overview
- Description of Products
- Natural Penicillins
- Penicillinase-Resistant Penicillins
- Broad -Spectrum Penicillins
- Extended-Spectrum Penicillins
- Natural Penicillins
- Penicillinase-Resistant Penicillins
- Broad-Spectrum Penicillins
- Extended-Spectrum Penicillins
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Seven: Quinolone Antibiotics
- Overview
- Description of Products
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Eight: Sulfonamide Antibiotics
- Overview
- Description of Products
- Market Size and Growth
- Competitive Analysis
Chapter Nine: Tetracycline Antibiotics
- Overview
- Description of Products
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Ten: Other Miscellaneous Antibiotics
- Overview
- Description of Products
- Aminoglycosides
- Lincomycin
- Chloramphenicol
- Glycopeptides
- Monobactams
- Carbapenems
- Carbacephems
- Metronidazole
- Antituberculars
- Antileprotics
- Oxazolidinones
- Ketolides
- Research and Development
- Market Size and Growth
- Competitive Analysis
Chapter Eleven: Total Market Size and Forecast Summary
- Overview
- Total Market Size and Forecast
chapter Twelve: Corporate Profiles
- Introduction
- Abbott Laboratories
- AstraZeneca plc
- Bayer AG
- Bristol-Myers Squibb Company
- Daiichi Pharmaceutical Company Ltd
- Fujisawa Pharmaceutical Company, Ltd.
- GlaxoSmithKline
- Johnson & Johnson Group
- Merck & Company, Inc.
- Pfizer, Inc.
- Roche
- Sanofi-Aventis
- Wyeth
APPENDIX: Company Names and Addresses
List of Exhibits
Chapter One: Executive Summary
- Table 1-1: The World Market for Antibacterial Drugs 2002-2009
- Figure 1-1: The World Market for Antibacterial Drugs 2002-2009
Chapter Two: Introduction
- Table 2-1: Micro-Organisms by Class and First- and Second-Choice Antibiotics
- Table 2-2: Estimated World and U.S. Incidence of Bacterial Infections
- Figure 2-1: Estimated World and U.S. Incidence of Leading Bacterial Infections
- Table 2-3: World Population by Selected Geographical Region, 2004-2050
- Figure 2-2: World Population by Selected Geographical Region, 2003-2050
- Table 2-4: Estimated World Population by Age and Geographical Region, 2004
- Figure 2-3: Estimated World Population by Age and Geographical Region, 2004
Chapter Four: Cephalosporin Antibiotics
- Table 4-1: Currently Available Cephalosporin Antibiotics by Generation (Type, Brand, and Manufacturer)
- Table 4-2: Cephalosporin Antibiotics in Development (Product, Developer, Development Phase, Earliest Approval Date)
- Table 4-3: The Market for Cephalosporin Antibiotics 2002-2009
- Figure 4-1: Cephalosporin Antibiotic Market 2002-2009
- Table 4-4: Cephalosporin Antibiotic Market Estimated Revenues by Infection Type 2004
- Figure 4-2: Cephalosporin Antibiotic Market Market Share by Infection Type, 2004
- Table 4-5: Cephalosporin Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 4-3: Cephalosporin Antibiotic Market Market Share by Geographic Region, 2004
- Table 4-6: Cephalosporin Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
- Figure 4-4: Cephalosporin Antibiotic Market Estimated Market Share by Leading Supplier 2004
- Table 4-7: Cephalosporin Antibiotic Market Estimated Sales and Market Share of Top Cephalosporin Antibiotic Product Brands 2004
- Figure 4-5: Cephalosporin Antibiotic Market Estimated Market Share of Top Cephalosporin Antibiotics, 2004
Chapter Five: Macrolide Antibiotics
- Table 5-1: Currently Available Macrolide Antibiotics (Type, Brand, and Manufacturer)
- Table 5-2: Macrolide Antibiotics in Development (Product, Developer, Indication, Development Phase, Earliest Approval Date)
- Table 5-3: The Market for Macrolide Antibiotics 2002-2009
- Figure 5-1: Macrolide Antibiotic Market 2002-2009 Table 5-4: Macrolide Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 5-2: Macrolide Antibiotic Market Market Share by Infection Type, 2004
- Table 5-5: Macrolide Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 5-3: Macrolide Antibiotic Market Market Share by Geographic Region, 2004
- Table 5-6: Macrolide Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
- Figure 5-4: Macrolide Antibiotic Market Estimated Market Share by Leading Supplier 2004
- Table 5-8: Macrolide Antibiotic Market Estimated Sales of Top Macrolide Antibiotic Products 2004
- Figure 5-8: Macrolide Antibiotic Market Estimated Market Share of Top Macrolide Antibiotics, 2004
Chapter Six: Penicillin Antibiotics
- Table 6-1: Currently Available Penicillin Antibiotics (Type, Brand, and Manufacturer)
- Table 6-2: Penicillin Antibiotics in Development (Product, Developer, Development Phase, Earliest Approval Date)
- Table 6-3: The Market for Penicillin Antibiotics 2002-2009
- Figure 6-1: Penicillin Antibiotic Market 2002-2009
- Table 6-4: Penicillin Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 6-2: Penicillin Antibiotic Market Market Share by Infection Type, 2004
- Table 6-5: Penicillin Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 6-3: Penicillin Antibiotic Market Market Share by Geographic Region, 2004
- Table 6-6: Penicillin Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
- Figure 6-4: Penicillin Antibiotic Market Estimated Market Share by Leading Suppliers 2004
- Table 6-7: Penicillin Antibiotic Market Estimated Sales of Top Penicillin Antibiotic Products 2004
- Figure 6-5: Penicillin Antibiotic Market Estimated Market Share of Top Penicillin Antibiotics, 2004
Chapter Seven: Quinolone Antibiotics
- Table 7-1: Currently Available Quinolone Antibiotics (Type, Brand, and Manufacturer)
- Table 7-2: Quinolone Antibiotics in Development
- Table 7-3: The Market for Quinolone Antibiotics 2002-2009 Compound Annual Growth Rate
- Figure 7-1: Quinolone Antibiotic Market 2002-2009
- Table 7-4: Quinolone Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 7-2: Quinolone Antibiotic Market Market Share by Infection Type, 2004
- Table 7-5: Quinolone Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 7-3: Quinolone Antibiotic Market Market Share by Geographic Region, 2004
- Table 7-6: Quinolone Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
- Figure 7-4: Quinolone Antibiotic Market Estimated Market Share by Leading Suppliers 2004
- Table 7-7: Quinolone Antibiotic Market Estimated Sales of Top Quinolone Antibiotics 2004
- Figure 7-5: Quinolone Antibiotic Market Estimated Market Share of Top Quinolone Antibiotics, 2004
Chapter Eight: Sulfonamide Antibiotics
- Table 8-1: Currently Available Sulfonamide Antibiotics (Type, Brand, and Manufacturer)
- Table 8-2: The Market for Sulfonamide Antibiotics 2002-2009
- Figure 8-1: Sulfonamide Antibiotic Market 2002-2009
- Table 8-3: Sulfonamide Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 8-2: Sulfonamide Antibiotic Market Market Share by Infection Type, 2004
- Table 8-4: Sulfonamide Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 8-3: Sulfonamide Antibiotic Market Market Share by Geographic Region, 2004
Chapter Nine: Tetracycline Antibiotics
- Table 9-1: Currently Available Tetracycline Antibiotics (Type, Brand, and Manufacturer)
- Table 9-2: Tetracycline Antibiotics in Development
- Table 9-3: The Market for Tetracycline Antibiotics 2002-2009
- Figure 9-1: Tetracycline Antibiotic Market 2002-2009
- Table 9-4: Tetracycline Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 9-2: Tetracycline Antibiotic Market Market Share by Infection Type, 2004
- Table 9-5: Tetracycline Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 9-3: Tetracycline Antibiotic Market Market Share by Geographic Region, 2004
Chapter Ten: Other Miscellaneous Antibiotics
- Table 10-1: Currently Available Other Miscellaneous Antibiotics (Type, Brand, and Manufacturer)
- Table 10-2: Other Miscellaneous Antibiotics in Development
- Table 10-3: The Market for Other Miscellaneous Antibiotics 2002-2009
- Figure 10-1: Other Miscellaneous Antibiotic Market 2002-2009
- Table 10-4: Other Miscellaneous Antibiotic Market Estimated Products Sales by Infection Type, 2004
- Figure 10-2: Other Miscellaneous Antibiotic Market Market Share by Infection Type, 2004
- Table 10-5: Other Miscellaneous Antibiotic Market Estimated Products Sales by Geographic Region, 2004
- Figure 10-3: Other Miscellaneous Antibiotic Market Market Share by Geographic Region, 2004
- Table 10-6: Other Miscellaneous Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
- Figure 10-4: Other Miscellaneous Antibiotic Market Estimated Market Share by Leading Suppliers 2004
- Table 10-7: Other Miscellaneous Antibiotic Market Estimated Sales of Top Other Miscellaneous Antibiotics 2004
- Figure 10-5: Other Miscellaneous Antibiotic Market Estimated Market Share of Top Other Miscellaneous Antibiotics, 2004
Chapter Eleven: Total Market Size and Forecast Summary
- Table 11-1: The World Market for Antibacterial Drugs 2002-2009
- Figure 11-1: The World Market for Antibacterial Drugs 2002-2009
- Table 11-2: Antibacterial Drug Market by Type 2002-2009
- Figure 11-2: The World Market for Antibacterial Drugs Revenues by Type 2002-2009
