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CAR-T Cell Therapy Market Review

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SKU: 19-099 Categories: Biopharmaceuticals Market Reports, Biotechnology Market Research Tags: "Off-the-Shelf" CAR-T Therapies, Acute lymphoblastic leukemia (ALL), CAR-T Cell Therapy Market, CAR-T Market Share, Diseases Treated with CAR-T, DLBCL B-cell lymphomas, Multiple myeloma Pages: 59
  • Description
  • Table of Contents
  • Latest reports

Description

CAR-T cell therapy is a form of immunotherapy that utilizes the body’s own T cells to target and destroy cancer cells. This therapy is a personalized form of treatment, meaning that each patient receives T cells that are geared specifically toward his or her cancer diagnosis. T-cell therapy works by removing existing T cells from a patient and having them grown and modified in a lab. These new T cells are given a gene for a specialized receptor, known as a chimeric antigen receptor (CAR), which allows the cells to specifically attack cancer cells. CAR-T cell therapy has shown effectiveness in eliminating cancer cells, especially for the following diseases:

  • Acute lymphoblastic leukemia (ALL)
  • DLBCL B-cell lymphomas
  • Multiple myeloma

CAR-T Cell Therapy Market Review discusses CAR-T’s impressive revenue growth, which is expected to continue given the effectiveness of the therapy and the projected new users. There are positive factors for the market, though there are limits to growth. Patient volume should increase, though it is likely that the unusually large prices will not sustain over the next five years. The report provides the following market data:

  • CAR-T Market, 2018-2024 ($millions)
  • CAR-T Market Share, 2019 (%)
  • CAR-T Market Regional Breakout, 2019 (%)

CAR-T Cell Therapy Market Review discusses CAR-T therapy market trends, issues, and recent developments, including the following:

  • Global Cancer Burden
  • Complexity of the CARs Manufacturing Process
  • Diseases Treated with CAR-T
  • Study Shows Yescarta Increases Longevity
  • CRS and Other Side Effects
  • China CAR-T Competition
  • Indian CAR-T Competition
  • “Off-the-Shelf” CAR-T Therapies in Development
  • Competing Therapy in Development

Also noted in the report are selected CAR-T therapies in development, an effort to capture current media coverage of CAR-T trials.

CAR-T Cell Therapy Market Review notes the activities of many of the major players in the market. The market companies that are covered in the report are the following:

  • AbbVie, Inc.
  • Autolus Therapeutics plc
  • Bellicum Pharmaceuticals, Inc.
  • bluebird bio, Inc.
  • Bristol-Myers Squibb Company
  • CARsgen Therapeutics
  • Celgene Corporation
  • Cellectis, Inc.
  • Celyad
  • Gilead Sciences, Inc.
  • GlaxoSmithKline
  • Immune Therapeutics
  • Innovative Cellular Therapeutics
  • Juno Therapeutics
  • Kite Pharma, Inc.
  • Mustang Bio
  • Novartis International AG
  • Pfizer, Inc.
  • Sorrento Therapeutics
  • ZIOPHARM Oncology, Inc.

Table of Contents

1: Executive Summary
Introduction
CAR-T Therapy Market Trends, Issues, and Recent Developments
CAR-T Therapy Market
Companies in the Market

2: CAR-T Cell Therapy Market
FDA-Approved CAR-T Therapies: Yescarta and Kymriah

  • Yescarta
  • Kymriah
    • Table 2-1: FDA-Approved CAR-T Therapies

CAR-T Therapy Market Trends / Issues

  • Global Cancer Burden
    • Figure 2-1: Global Cancer Incidence Trends, 2010-2040
  • Complexity of the CARs Manufacturing Process
  • Diseases Treated with CAR-T

Recent Market Developments

  • Study Shows Yescarta Increases Longevity
  • CRS and Other Side Effects
  • China CAR-T Competition
  • Indian CAR-T Competition
  • “Off-the-Shelf” CAR-T Therapies in Development
  • A Competing Therapy in Development

Selected CAR-T Therapies in Development

    • Table 2-2: Selected CAR-T Therapies in Development
  • KTE-X19
  • liso-cel
  • C-CAR088
  • IBI326 (Innovent) / CT103A (IASO BIO)
  • bb21217
  • MB-107
  • ICTCAR014
  • bb2121
  • JNJ-682284528 (JNJ-4528)
  • CT053
  • MB-101 (IL-13Ra2)
  • MB-108 (oncolytic virus C134)
  • CYAD-01
  • BAFF-R CAR-T
  • MB-105 (PSCA)
  • MB-102 (CD123)
  • MB-103 (HER2)
  • P-BCMA-101
  • LCAR-B38M
  • JCARH125
  • MCARH171
  • CYAD-101
  • MB-106 (CD20)
  • MB-104 (CS1)
  • AMG 119
  • ATA2271
  • AUTO1
  • AUTO3

CAR-T Market Analysis

    • Figure 2-2: CAR-T Market, 2018-2024 ($millions)
  • Market Share
    • Figure 2-3: CAR-T Market Share, 2019 (%)
  • Regional Breakout
    • Figure 2-4: CAR-T Market Regional Breakout, 2019 (%)

3: Companies in the Market
AbbVie, Inc.

  • Company Summary
  • Scripps Research Institute Deal
  • Tyrosine Kinase Inhibitors Market

Autolus Therapeutics plc
Bellicum Pharmaceuticals, Inc.
bluebird bio, Inc.

  • Company Summary
  • bb2121
  • bb21217
  • bb2121

Bristol-Myers Squibb Company

  • Company Summary
  • BMS Acquires Celgene
  • Monoclonal Antibodies Market
  • Cancer Kinase Inhibitor Market

CARsgen Therapeutics
Celgene Corporation

  • Company Summary
  • Collaboration with Immatics Biotechnologies
  • Celgene Acquires Juno, Developer of CAR-T and TCR Therapeutics, for $9 Billion
  • Celgene Buys JAK2 Inhibitor Maker

Cellectis, Inc.

  • Pfizer
  • Servier

Celyad

  • CYAD-01
  • CYAD-101

Gilead Sciences, Inc.
GlaxoSmithKline
Gracell Biotechnology
Immune Therapeutics

  • CAR-T

Innovative Cellular Therapeutics

  • ICTCAR014

Juno Therapeutics

  • Selected CAR-T Therapies in Development
  • Collaboration with Editas Medicine

Kite Pharma, Inc.

  • KTE-X19
  • Yescarta

Mustang Bio
Novartis International AG

  • Company Summary
  • Kymriah
  • Intellia Therapeutics
  • Other Company Activity

Pfizer, Inc.
Sorrento Therapeutics
ZIOPHARM Oncology, Inc.

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