Table of Contents

1: EXECUTIVE SUMMARY

INTRODUCTION

LARGE-SCALE MICROBIOME PROJECTS

SCOPE OF THE REPORT

METHODOLOGY

2: HUMAN MICROBIOME IN IVD AND OTHER HEALTHCARE APPLICATIONS

MICROBIOME – BACTERIA IN DISEASE PROCESSES

GROWING INTEREST IN THE MICROBIOME

METAGENOMICS

METABOLOMIC PROFILING

MICROBIOME DIAGNOSTICS

Table 2-1: Selected Microbiome-based Tests

Selected Molecular Microbiome-based Tests

Diagnostic Biomarkers

Precision or Personalized Medicine Approaches

PHARMA COMPANY INTEREST IN THE MICROBIOME

Agreements, Investments

Fecal Microbiota Transplantation (FMT)

Other Selected Microbiome-related Therapeutic Approaches

Microbiome Modulators

INVESTMENT IN MICROBIOME COMPANIES

Table 2-2: Selected Investments in Microbiome Companies

3: SELECTED MICROBIOME PLAYERS

4D PHARMA PLC

GT Biologics

ABBOTT DIAGNOSTICS

Company Overview

IRIDICA

The Microbiome Coalition

ABBVIE

Synlogic Partnership

ACES HEALTH

ADVANCINGBIO

AGILENT TECHNOLOGIES INC.

ANAEROPHARMA SCIENCE

AOBIOME, LLC

APERIOMICS, INC.

ARIVALE

ATLAS BIOMED

AVIDBIOTICS

Pylum Biosciences, Inc.: Microbiome-focused Company with Precision Anti-Bacterial Technology

Xyphos, Inc.: Immuno-Oncology Focused Company with Flexible CAR-T Technology

BECKMAN COULTER / DANAHER

BECTON, DICKINSON AND COMPANY (BD)

Cytology

BD Max Molecular

ID/AST

POC Veritor

Mass Spectrometry

Blood Collection

Flow Cytometry

Licensing

BIOCARTIS GROUP

Microbiome

Company Overview

THE BIOCOLLECTIVE

BIOGAIA PHARMA AB

BIOHIT OYJ

Microbiome

Company Overview

Market Expansion

BIOMECITE DIAGNOSTICS

BIOMÉRIEUX INC.

Traditional Microbiology

Blood Culture

Immunoassays

Mass Spectrometry

Platelet Safety

Sequencing

Sequencing – Sample Preparation, Molecular

Data Analysis

BioFire Diagnostics Business

BIO-RAD LABORATORIES, INC

Microbiome

Company Overview

Quality Control

Blood Bank

Infectious Diseases – Molecular

Immunoassays

Liquid Biopsy

Droplet Digital PCR

Sequencing

BIOSE

BLIS TECHNOLOGIES

BRUKER CORPORATION

Microbiome

Company Overview

C3J THERAPEUTICS (FORMERLY C3 JIAN)

CAPSUGEL

CHARLES RIVER LABORATORIES, INC.

Microbiome

History and Lines of Business

Drug Discovery Services

CIPAC THERAPEUTICS

CLC BIO (A QIAGEN COMPANY)

CLINICAL-MICROBIOMICS

COPAN DIAGNOSTICS, INC.

Lab Automation

Partnerships

Swabs

COSMOSID

COVARIS

Sample Prep for Microbiome Research

Company Overview

CRESTOVO (FINCH THERAPEUTICS GROUP)

DANAHER CORPORATION

Company Overview

Mass Spectrometry

Danaher Buys Phenomenex

DERMALA

DERMTECH

DIVERSIGEN

DNA GENOTEK

DNANEXUS, INC

EAGLE GENOMICS

ELIGO BIOSCIENCE

ENTEROME BIOSCIENCE SA

Bristol-Myers Squibb

Vertex Pharmaceuticals

Takeda Pharmaceutical

Janssen Biotech

Nestle Health Science

EPIBIOME

Company Overview

Partnerships and Collaborations

EPPENDORF AG

EVELO BIOSCIENCES

EVOLVE BIOSYSTEMS

FINCH THERAPEUTICS GROUP

GALT

GATC BIOTECH AG

GENETIC ANALYSIS AS

Company Overview

Agreement with Bio-Rad

GENEWIZ, INC.

GLAXOSMITHKLINE PLC

Company Overview

Microbiome-related Developments

HUMAN LONGEVITY, INC. (HLI)

ILLUMINA

Sequencing

Microbiome-related Developments

IS-DIAGNOSTICS

ISOTHRIVE LLC

JANSSEN BIOTECH (JOHNSON & JOHNSON)

The Janssen Human Microbiome Institute (JHMI)

Table 3-1: Janssen Human Microbiome Institute (JHMI), Already Existing Microbiome Collaborations with Biotechnology Companies and Academic Institutions, February 2015

MOSAIC Microbiome Platform

License Agreement with Vedanta Biosciences

KALLYOPE

LABCYTE

LUMINEX CORPORATION

Microbiome-related Developments

Company Overview

Assay Development

Verigene Business

Business Expansion

MAYO MEDICAL LABORATORIES

MENARINI-SILICON BIOSYSTEMS

MERCK & CO., INC.

METABIOMICS CORPORATION

METABOGEN AB

METABOLON, INC.

Company Overview

Precision Metabolomics

Partnerships and Collaborations

MICROBIOME

MICROBIOME INSIGHTS

MICROBIOME THERAPEUTICS (MBT)

Company Overview

Technology

MITRA BIOTECH

MYBIOTICS

NAKED BIOME

NESTLÉ HEALTH SCIENCE

Company Overview

Microbiome-related Development

NEW ENGLAND BIOLABS

Company Overview

Microbiome-related Development

NIZO

NORGEN BIOTEK

ONCOIMMUNITY

ONE CODEX

Company Overview

Microbiome-related Development

OPENBIOME

Company Overview

Finch Therapeutics

OPTIBIOTIX

Company Overview

Technology Platforms

ORASURE TECHNOLOGIES, INC.

Company Overview

The Genotek Business

OSEL, INC.

Company Overview

Portfolio

PERKINELMER, INC. (PE)

Company Overview

Diagnostics

Sample Prep

Sequencing

Histology

Prenatal Business

Lab Services

Expansion

PFIZER, INC.

PHASE GENOMICS

PRODERM IQ

PRODIGEST

PROMEGA CORPORATION

PUREFLORA INC.

QIAGEN

QIAGEN Bioinformatics

QUAY PHARMA

REBIOTIX

RESPHERA BIOSCIENCES

RITTER PHARMACEUTICALS, INC.

Company Overview

RP-G28

ROCHE DIAGNOSTICS

Company Overview

Microbiome-related Developments

SABINSA CORPORATION

SCREENCELL

SECOND GENOME

SERES THERAPEUTICS

Collaboration with The University of Texas MD Anderson Cancer Center and the Parker Institute for Cancer Immunotherapy

Biotherapies for Infection Treatment

Selected Products in Development

SHIMADZU CORPORATION

SIOLTA THERAPEUTICS

SYMBIOTIC HEALTH

SYNCO BIO PARTNERS B.V.

SYNLOGIC

Company Overview

AbbVie Partnership

SYNTHETIC BIOLOGICS

Company Overview

SYN-004 (ribaxamase)

SYN-010

THERMO FISHER SCIENTIFIC, INC.

Microbiome-related Development

Company Overview

TNO

TRISKELION

UBIOME

VAIOMER

VEDANTA BIOSCIENCES

VIOME

VITHERA PHARMACEUTICALS

WATERS CORPORATION

WHOLE BIOME

XYCROBE THERAPEUTICS, INC.

Company Overview

Research Agreement with Johnson & Johnson Consumer

ZYMO RESEARCH