Table of Contents

1: EXECUTIVE SUMMARY

OVERVIEW

Focus on Cost Effectiveness

Outsourcing Popular

Flexibility and More

Research Needed

Table 1. World Market for Downstream Bioprocessing Components, 2016-2021 ($ billions)

METHODOLOGY

2: INTRODUCTION

DOWNSTREAM PROCESSING

Table 2. The State of Downstream Bioprocessing

Important Roles

Table 3. Key Roles of Downstream Bioprocessing

Safety and EfficacySTAGES OF DOWNSTREAM PROCESSING

Table 4. Stages of Downstream Bioprocessing

Solid-Liquid SeparationIntracellular Product ReleaseProduct ConcentrationChromatography PurificationFormulationCHANGES IN PRODUCTION NATURE

Table 5. Current Biopharmaceutical Product Mix

Innovation RequiredGlobalization ContinuesTHE NEED FOR OPERATIONAL EXCELLENCECOMPETITION GENERATING COST EFFICIENCIESDownstream ResistanceProcess IntensificationHigher TitersNew TechnologiesFlexibilityIntegration and AutomationContinuous ProcessingDEVELOPING RESEARCH AREASChromatographyResinsAlternative Processes for PurificationSpectroscopyFILTRATION TECHNOLOGIES ADVANCETangential FlowAutomatedGel Filtration ChromatographyPrecipitation AlternativeSlow Adoption of New TechnologiesOUTSOURCINGCore CompetenciesDriversIssuesThe Future

3: TRENDS AND DRIVERS

Table 6. Key Trends in Downstream Bioprocessing

PROTEIN AMOLECULE ISSUESCHROMATOGRAPHY

Table 7. Application of Single Use Technology Downstream (percentage of overall use)

STREAMLINING AND REDESIGNINGStreamlining NichesPURIFICATIONGREATER USE OF CONTRACT MANUFACTURERSPRODUCTION EFFICIENCYINTERNATIONALCANCER THERAPY PUSHCOLLABORATIONS AND INNOVATION

4: CHALLENGES

CHROMATOGRAPHYCONTINUOUS PROCESSINGTITERS AND COMPOSITIONEVOLVING CLARIFICATION AND PURIFICATION STRATEGIESCAPACITY BOTTLENECKSISOLATION OF PROTEINSEFFICIENCIESQUALITY BY DESIGNTALENT SHORTAGE

5: MARKET DEVELOPMENTS

COLLABORATION TO IMPROVE DOWNSTREAM BIOPROCESSING

START-UP ACQUISITION

PROMOTING PRE-PACKED COLUMNS

NEXT GENERATION COLUMNS

NEXT GENERATION AFFINITY LIGANDS

IMMUNOGLOBULIN FACILITY

BIOPROCESSING SERVICES

EXPANSION

ACQUISITION

SUPPLY DEAL

BIOCONJUGATION PROCESS

NEW STRUCTURED SUBSTRATES

NEW PROTEIN A CHROMATOGRAPHY RESIN

ENTERPRISE SOFTWARE INCREASES THROUGHPUT AND QUALITY

INVESTING IN PROTEIN EXPRESSION PLATFORM

6: MARKET LANDSCAPEOVERVIEWDRIVERS

Table 8. Key Drivers of Downstream Bioprocessing

Expanding Therapies and MarketsMARKET ANALYSIS AND FORECASTSBiosimilarsGrowth and Emerging MarketsContinuous ProcessingGLOBAL MARKET FOR DOWNSTREAM BIOPROCESSING COMPONENTS

Table 9. Downstream Components Bioprocessing Market Share by Vendor 2018 (%)

Table 10. World Downstream Bioprocessing Markets, 2016-2021 ($ billions)

Table 11. World Downstream Bioprocessing Markets by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)

Table 12. World Downstream Bioprocessing Markets by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Chromatography Columns and Resins

Table 13. World Downstream Bioprocessing Chromatography Columns and Resins Markets, 2016-2021 ($ billions)

Table 14. World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)

Table 15. World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Membrane Adsorbers

Table 16. World Downstream Bioprocessing Membrane Adsorber Market, 2016-2021 ($ millions)

Table 17. World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)

Table 18. World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Filtration Systems

Table 19. World Downstream Bioprocessing Filtration Market, 2016-2021 ($ billions)

Table 20. World Downstream Bioprocessing Filtration Market by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)

Table 21. World Downstream Bioprocessing Filtration Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Sensors

Table 22. World Downstream Bioprocessing Sensor Market, 2016-2021 ($ billions)

Table 23. World Downstream Bioprocessing Sensor Market by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)

Table 24. World Downstream Bioprocessing Sensor Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

7: CORPORATE PROFILES3M COMPANY, ST. PAUL, MN 55144, WWW.3M.COM/3M/EN_US/COMPANY-USABEC, BETHLEHEM, PA 18017, WWW.ABEC.COMALFA LAVAL, LUND, SWEDEN, WWW.ALFALAVAL.COMAVANTOR PERFORMANCE MATERIALS, CENTER VALLEY, PA 18034, WWW.AVANTORINC.COMBIA SEPARATIONS, AJDOVŠČINA, SLOVENIA, WWW.BIASEPARATIONS.COMBOEHRINGER INGELHEIM PHARMACEUTICALS, RIDGEFIELD, CT 06877, WWW.BIOXCELLENCE.COMBOSCH, STUTTGART, GERMANY, WWW.BOSCH.DE/EN/DOW, MIDLAND, MI, WWW.DOW.COMESI ULTRAPURE, CWMBRAN, TORFAEN, NP44 3XS, UK, WWW.ESIULTRAPURE.COMFINESSE SOLUTIONS, SANTA CLARA, CA 95054, WWW.FINESSE.COMFUJIFILM DIOSYNTH BIOTECHNOLOGIES, COLLEGE STATION, TX 77845, WWW.FUJIFILMDIOSYNTH.COMGE HEALTHCARE LIFE SCIENCES, MARLBOROUGH, MA 01752, HTTPS://WWW.GELIFESCIENCES.COM/ SOLUTIONS/BIOPROCESSING/PRODUCTS-AND-SOLUTIONS/DOWNSTREAM-BIOPROCESSINGGEA GERMANY DÜSSELDORF, 40468 DÜSSELDORF, GERMANY, WWW.GEA.COM/ENLONZA GROUP, BASEL, SWITZERLAND, WWW.LONZA.COMMILLIPORE, MILLIPORE SIGMA, BURLINGTON, MA 01803, WWW.EMDMILLIPORE.COMNATRIX SEPARATIONS, BURLINGTON, ONTARIO, L7L 6A8 CANADA, WWW.NATRIXSEPARATIONS.COMNORDSON MEDICAL, MARLBOROUGH, MA 01752, WWW.NORDSONMEDICAL.COMPALL BIOTECH, PORT WASHINGTON, NY 11050, HTTPS://BIOTECH.PALL.COMPARKER HANNIFIN, CLEVELAND, OH 44124, WWW.PARKER.COMREPLIGEN, WALTHAM, MA 02453, WWW.REPLIGEN.COMSARTORIUS AG, GOETTINGEN, GERMANY, WWW.SARTORIUS.COMTHERMO FISHER SCIENTIFIC, WALTHAM, MA 02451, HTTPS://WWW.THERMOFISHER.COM/US/EN/HOME/LIFE-SCIENCE/BIOPRODUCTION.HTMLW. L. GORE & ASSOCIATES, INC., NEWARK, DE 19711, WWW.GORE.COMWATSON-MARLOW FLUID TECHNOLOGY GROUP, FALMOUTH, TR11 4SZ UK, WWW.WATSON-MARLOW.COM